Fcγ receptor IIIb
| Fcγ receptor IIIb | ||
|---|---|---|
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| according to PDB 1E4J | ||
| other names |
Fc-gamma RIII-beta, Fc-gamma RIII, Fc-gamma RIIIb, FcRIII, FcRIIIb, Low affinity immunoglobulin gamma Fc region receptor III-B |
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| Properties of human protein | ||
| Mass / length primary structure | 233 amino acids , 26,216 Da | |
| Identifier | ||
| External IDs | ||
Fcγ receptor IIIb (synonym CD16b , FcγRIIIβ ) is a surface protein from the group of Fc receptors .
properties
CD16b binds as an Fcγ receptor to the Fc region of immunoglobulin G , with or without bound antigens . It is made by neutrophils and stimulated eosinophils . In contrast to the closely related CD16a , it has no ITAM and is not involved in antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis . CD16b is glycosylated and has a GPI anchor .
Web links
Individual evidence
- ↑ P. Selvaraj, N. Fifadara, S. Nagarajan, A. Cimino, G. Wang: Functional regulation of human neutrophil Fc gamma receptors. In: Immunologic research. Volume 29, Numbers 1-3, 2004, pp. 219-230, doi: 10.1385 / IR: 29: 1-3: 219 , PMID 15181284 .
- ↑ P. Selvaraj, WF Rosse, R. Silber, TA Springer: The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria . In: Nature . tape 333 , no. 6173 , June 9, 1988, ISSN 0028-0836 , pp. 565-567 , doi : 10.1038 / 333565a0 , PMID 2967435 .