Focal cortical dysplasia

from Wikipedia, the free encyclopedia

As focal cortical dysplasia , often abbreviated as FKD or English. as FCD , the most common group of cortical malformations designated. These are subtle focal disorders of the development of the cerebral cortex , which are often associated with epilepsy . A common classification of focal cortical dysplasia is the Palmini classification. Patients with focal cortical dysplasia of the Taylor type (Palmini type II) seem to have a more favorable postoperative course with greater freedom from seizures after epilepsy surgery.

Type according to Palmini et al. histology frequency
Type IA Isolated structural abnormality of the architecture of the cortex cerebri ( heterotopic nerve cells in the medullary bed ) 60%
Type IB Structural abnormality of the architecture of the cerebral cortex with evidence of so-called giant neurons 11%
Type IIA (Taylor type FCD) : Architectural abnormalities of the cerebral cortex with evidence of dysmorphic nerve cells 4%
Type IIB (Taylor type FCD) : Architectural abnormalities of the cerebral cortex with evidence of bizarre balloon cells 25%

See also

literature

Individual evidence

  1. ↑ [1]
  2. ↑ Colombo et al .: Focal cortical dysplasias: MR imaging, histopathologic, and clinical correlations in surgically treated patients with epilepsy. AJNR Am J Neuroradiol. 2003; 24 (4): 724-33. PMID 12695213 full text
  3. ^ Taylor & Falconer: Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 1971; 34: 369-387 PMID 5096551
  4. ↑ a b Palmini et al .: Terminology and classification of the cortical dysplasias. Neurology. 2004; 62 (6 Suppl 3): S2-8 PMID 15037671
  5. ↑ a b Tassi et al .: Focal cortical dysplasia: neuropathological subtypes, EEG, neuroimaging and surgical outcome. Brain, 2002; 125 (8) 1719-1732 PMID 12135964 full text