Glycomic

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Glycomics , a term analogous to genomics and proteomics , describes the systematic investigation of all glycan structures of a cell type or an organism in biochemistry . It is part of glycobiology . In particular, modifications of proteins by attached carbohydrates ( glycosylation ) and their function and effects are investigated. Glykomik also includes the creation of novel biopharmaceutical protein-based bioactive ingredients .

The human genome harbors genes for at least 250 different glycosyltransferases . The majority of these are located in three enzyme families, each of which can cladistically be traced back to a parent form.

Web links

Individual evidence

  1. Ajit Varki: Essentials of glycobiology . 2nd Edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 2009, ISBN 978-0-87969-770-9 .
  2. Gerald W. Hart, Ronald J. Copeland: Glycomics hits the big time. In: Cell . 143, No. 5, 2010, pp. 672-676. doi: 10.1016 / j.cell.2010.11.008 .
  3. J. Liu, A. Mushegian: Three monophyletic super families account for the majority of the known glycosyltransferases . In: Protein Sci . 12, No. 7, July 2003, pp. 1418-1431. doi : 10.1110 / ps.0302103 .