Graham Little Syndrome

Classification according to ICD-10
L66.1	Lichen planopilaris, lichen planus follicularis
ICD-10 online (WHO version 2019)

The Graham-Little-Syndrome or Picardi-Lassueur-Little-Syndrome is a very rare special form of lichen planus ( lichen planus ) with the characteristics of scarring alopecia (hair loss) of the scalp, but also in the armpit and groin, changes in the hairless skin (follicular keratotic papules) and structural disorder of the fingernails or toenails ( nail dystrophy ).

The name refers to the author of the first publication in 1915 by the British dermatologist Sir Ernest Graham Little . The Italian G. Piccardi had already published a report a year earlier .

Occurrence and cause

The prevalence is unknown, but the disease is very rare. The cause is also unknown. Women between the ages of 30 and 60 are mostly affected.

Clinical manifestations

Scarred alopecia has small confluent spots with a scarred center and reddened, scaly edges.
In follicular keratosis, itchy, red-brown, follicular papules appear on the trunk and extremities.

literature

E. Keining, B. Rathjens: [Attempt at delimitation of the Graham-Little syndrome]. In: Dermatologische Wochenschrift. Vol. 132, No. 38, 1955, pp. 1016-1023, ISSN 0366-8940 . PMID 13261637 .
A. Baibergenova, J. Donovan: Lichen planopilaris: update on pathogenesis and treatment. In: Skinmed. Volume 11, Number 3, 2013 May-Jun, pp. 161-165, ISSN 1540-9740 . PMID 23930355 . (Review).

Individual evidence

↑ ^a ^b ^c Graham-Little Syndrome. In: Orphanet (Rare Disease Database).
^ W. Pschyrembel: Clinical dictionary. 265th edition. Verlag Walter de Gruyter, 2014, ISBN 978-3-11-018534-8 .
↑ EG Little: Folliculitis Decalvans et Atrophicans. In: Proceedings of the Royal Society of Medicine. Volume 8, Dermatol Sect 1915, pp. 139-141, ISSN 0035-9157 . PMID 19978527 . PMC 2004405 (free full text).
↑ G. Piccardi: Cheratosi spinulosa del capillizio a suoi rapporti con al pseudo-pelade di Brocq. In: Giornale Italiano della Malattie Veneree e della Pelle. 1914, volume 49, p. 416.

[Orpha-1] Graham-Little Syndrome. In: Orphanet (Rare Disease Database).

[2] W. Pschyrembel: Clinical dictionary. 265th edition. Verlag Walter de Gruyter, 2014, ISBN 978-3-11-018534-8 .

[3] EG Little: Folliculitis Decalvans et Atrophicans. In: Proceedings of the Royal Society of Medicine. Volume 8, Dermatol Sect 1915, pp. 139-141, ISSN 0035-9157 . PMID 19978527 . PMC 2004405 (free full text).

[4] G. Piccardi: Cheratosi spinulosa del capillizio a suoi rapporti con al pseudo-pelade di Brocq. In: Giornale Italiano della Malattie Veneree e della Pelle. 1914, volume 49, p. 416.