Granuloma inguinale
| Classification according to ICD-10 | |
|---|---|
| A58 | Granuloma venereum (inguinale) |
| ICD-10 online (WHO version 2019) | |
Granuloma inguinale is a bacterial disease that has characteristic ulcerating lesions in the genital area, also known as donovanosis after the discoverer of the pathognomonic histological structures, or Granuloma genitoinguinale. In 1905 the tropical doctor Charles Donovan described the bacterial disease for the first time. The pathogen is Klebsiella granulomatis (formerly Calymmatobacterium granulomatis ).
It is endemic in many developing countries . Due to several problems (which apply to almost all STDs ) the inguinal granuloma often remains untreated there and can grow destructively.
The bacterium is transmitted through close skin contact. The venereal disease is visible in the area of the external genital organs and in the area of the anus . It may take a few days or several weeks before the first symptoms appear.
The painless ulcerations, which can be mistaken for syphilis, ultimately progress into tissue destruction and profuse bleeding. This surface degradation increases the risk of further microbial superinfection and can also lead to mutilation.
diagnosis
Diagnosis is based on medical history and clinical examination showing a painless ulcer with a characteristically rolled edge of granulation tissue. Unlike ulcerations that occur in syphilis, there is usually no lymph node involvement. Tissue biopsies and Wright-Giemsa stain help make the diagnosis. Here, the donovan bodies appear deep purple as rod-shaped oval organisms in the cytoplasm of macrophages or histiocytes.
therapy
The therapy can be carried out with co- trimoxazole , tetracyclines or macrolides . Even after treatment with antibiotics, it can relapse for up to 18 months. Sexual partners who had sexual intercourse with the affected person up to 40 days before the onset of the disease can also be affected. Sexual intercourse should be avoided until it is completely healed.
Individual evidence
- ↑ a b Herbert Renz-Polster , Steffen Krautzig, Jörg Braun: Basic textbook internal medicine with StudentConsult access: compact-tangible-understandable . 4th edition. Urban & Fischer Verlag / Elsevier, 2008, ISBN 3-437-41053-9 .
- ↑ Granuloma inguinale. July 1, 2016, accessed January 29, 2017 .
- ↑ a b Pschyrembel Clinical Dictionary . 260th edition. Gruyter, 2004, ISBN 3-11-017621-1 .
Web links
- WHO sexually transmitted infections. Retrieved July 3, 2011 .
