Klebsiella granulomatis
| Klebsiella granulomatis | ||||||||||||
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| Scientific name | ||||||||||||
| Klebsiella granulomatis | ||||||||||||
| (Aragão & Vianna 1913) Carter et al. 1999 |
Klebsiella granulomatis is a facultatively anaerobic , gram-negative rod bacterium . This bacterium can be transmitted through sexual intercourse and causes what is known as donovanosis .
features
Like all Klebsiella species, Klebsiella granulomatis facultatively forms anaerobic, non-motile, non-spore-forming rods, but it is pleomorphic , i.e. that is, they are very diverse. The rods can be straight or curved, but cocci and diplococci also occur. Ripe forms form egg-shaped to elliptical capsules that are 0.5 to 0.7 µm wide and 1 to 1.5 µm long. Immature forms, on the other hand, do not form capsules, are more coke-shaped and measure 0.6 to 1 µm.
Klebsiella granulomatis grows intracellularly and colonizes the cytoplasm of large mononuclear cells and occasionally polymorphonuclear leukocytes . The germ was isolated from chicken embryos from their developed brain and the yolk sac . Culture media therefore often contain yolks. The optimal growth temperature is 37 ° C.
Clinical picture
Klebsiella granulomatis can be transmitted through sexual intercourse and is therefore an STD . It triggers what is known as donovanosis, also known as granuloma inguinale . This is not to be confused with the lymphogranuloma inguinale , which is caused by Chlamydia trachomatis (see Granuloma inguinale)
Sensitivity to antibiotics
Like many gram-negative bacteria, Klebsiella granulomatis is also resistant to β-lactam antibiotics . The treatment is done with tetracyclines such as doxycycline or cotrimoxazole , alternatively also with quinolone antibiotics and (especially during pregnancy) macrolides (e.g. erythromycin ). All sexual partners should undergo treatment (post-exposure prophylaxis) to avoid the ping-pong effect .
Systematics
Klebsiella granulomatis was described by Aragão and Vianna as Calymmatobacterium granulomatis . Carter et al. showed a very high genetic match (over 99%) with Klebsiella pneumoniae and Klebsiella rhinosleromatis and therefore placed the bacterium in the genus Klebsiella . Other synonyms are Encapsulatus inguinalis (Bergey 1923) and Donovania granulomatis (Anderson et al. 1944).
literature
- JS Carter, FJ Bowden, I. Bastian, GM Myers, KS Sriprakash, DJ Kemp: Phylogenetic evidence for reclassification of Calymmatobacterium granulomatis as Klebsiella granulomatis comb. nov. In: International journal of systematic bacteriology. Volume 49 Pt 4, October 1999, pp. 1695-1700, ISSN 0020-7713 . PMID 10555350 .
Individual evidence
- ↑ Klebsiella ( Memento of the original from November 8, 2011 in the Internet Archive ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice.
- ↑ Basic textbook internal medicine: compact, tangible, understandable / ed. by Herbert Renz-Polster ; Steffen Krautzig , 4th, completely revised. Edition, Elsevier, Urban & Fischer, Munich 2008, ISBN 978-3-437-41053-6 .
- ^ Pschyrembel Clinical Dictionary , 260th edition, Gruyter, 2004, ISBN 3110176211 .
- ↑ Henrik Holtmann, Monika Bobkowski: BASICS Medical Microbiology, Virology and Hygiene , 1st edition, Urban & Fischer Verlag / Elsevier GmbH, May 19, 2008, ISBN 9783437424168 .
- ^ Marianne Abele-Horn: Antimicrobial Therapy. Decision support for the treatment and prophylaxis of infectious diseases. With the collaboration of Werner Heinz, Hartwig Klinker, Johann Schurz and August Stich, 2nd, revised and expanded edition. Peter Wiehl, Marburg 2009, ISBN 978-3-927219-14-4 , p. 264.
