Gullo syndrome

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The Gullo syndrome (including benign pancreatic Hyperenzymämie) is a syndrome in humans, the chronic increase of pancreatic enzymes is characterized in the blood. It was named after the Italian pancreatologist Lucio Gullo and probably has no disease value of its own.

frequency

In hospital patients without directly recognizable disease of the pancreas , increases in amylase and / or lipase were found in 8% . In 11% of these patients, pathological processes in the pancreas were found in the further course. In a further study, a prevalence of increased lipase values ​​of 3.4% could be shown in a population of more than 4000 people in West Pomerania . The increase in pancreatic enzymes can have a variety of causes, such as kidney failure or advanced age. So the numbers are not to be understood as the actual prevalence of Gullo syndrome.

diagnosis

The syndrome is characterized by an increase in one or more of the pancreatic enzymes amylase , lipase, and trypsin . The values ​​can be up to 18 times above the upper reference values. The increase can be recurring or permanent and typically shows strong fluctuations between consecutive days. If there is such an increase in pancreatic enzymes with normal examination results and without known previous diseases of the pancreas, an ultrasound examination of the organ should be carried out by an experienced examiner under optimal sound conditions. Repeated measurements of the enzymes do not seem to make sense due to the strong fluctuations in the values. Especially in patients older than 50 years, the diagnosis of the harmless Gullo syndrome should only be made after a follow-up of 1 to 2 years in order to rule out serious diseases of the pancreas.

causes

A genetic cause of the syndrome is suspected. Imaging procedures such as CT and MRI do not show any morphological abnormalities.

Individual evidence

  1. ↑ a b L. Gullo: Chronic nonpathological hyperamylasemia of pancreatic origin In: Gastroenterology. 1996, 110, pp. 1905-1908.
  2. ↑ a b c d e P. G. Lankisch: Elevated pancreatic enzymes without recognizable pancreatic disease In: German Medical Weekly . 2009, 134, pp. 2232-2235.
  3. ↑ L. Gullo, L. Lucrezio, M. Migliori et al.: Benign pancreatic hyperenzymemia or Gullo's syndrome In: Advances in Medical Science. 2008, 53, pp. 1-5.