Helix bundle

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Example of a 4-helix bundle from the side.

The helix bundle is a conserved protein fold made up of several α-helices that are arranged parallel or antiparallel to one another. The hydrophobic parts of the individual α-helices are arranged facing inwards and the hydrophilic parts facing outwards in order to create a hydrophilic surface. Inside the bundle, for. B. Cofactors are bound.

For example, the 3 or 4 helix bundles are known.

Individual evidence

  1. S Kamtekar, Michael Hecht: Protein Motifs. 7. The four-helix bundle: what determines a fold? In: FASEB journal: official publication of the Federation of American Societies for Experimental Biology . tape 9 , September 1, 1995, pp. 1013–22 , doi : 10.1096 / fasebj.9.11.7649401 ( researchgate.net [accessed February 4, 2020]).