Heptad pattern

As Heptadenmuster or heptad repeat (English: heptad repeat ) refers to a sequence motif , in which hydrophobic amino acid residues at the 1st and 4th position are a seven-amino acid segment. The motif can be described as follows:

 a b c d e f g             H: hydrophober Aminosäurerest
 H P P H C P C             P: polarer Aminosäurerest
                           C: elektrisch geladener Aminosäurerest (engl. charged residue)

The individual amino acid residues are noted with the minuscules from a to g . If you continue the sequence, write from a 'to g ', a '' to g '' etc.

This motif is a distinctive structure of coiled coils , especially the bZIP domain . The coiled coil structure is stabilized by the hydrophobic interaction of these amino acids.

literature

• Jeremy M. Berg, Lubert Stryer , John L. Tymoczko: Stryer Biochemistry. Springer-Verlag, Berlin, Heidelberg 2014, ISBN 978-3-8274-2989-6 .

Individual evidence

1. ↑ P. Chambers, CR Pringle, AJ Easton: Heptad repeat sequences are located adjacent to hydrophobic regions in several types of virus fusion glycoproteins. In: The Journal of general virology. Volume 71 (Pt 12), December 1990, pp. 3075-3080, doi : 10.1099 / 0022-1317-71-12-3075 , PMID 2177097 .