I f channel inhibitors

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I f channel inhibitors are a new class of substances with the lead substance ivabradine . They specifically inhibit the opened I f channel ( HCN4 from the HCN channel group) on the heart and thus lower the heart rate . I are used for channel inhibitors for the treatment of chronic stable angina pectoris in patients with normal sinus rhythm , in which beta-blockers contraindicated are incompatible or insufficiently effective.

Individual evidence

  1. ↑ Entry on ivabradine. In: Römpp Online . Georg Thieme Verlag, accessed on September 3, 2013.
  2. ↑ Mutschler, Ernst: Mutschler drug effects. Pharmacology, clinical pharmacology, toxicology. 10th edition. Stuttgart 2013.