Comedogenicity

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Comedogenicity describes the property of promoting the formation of comedones in the ducts of the sebum follicles .

Determination of comedogenicity

The rabbit ear model was used to investigate the comedogenicity of chemical substances. The rabbit ear model is an animal model , but its transferability to the human situation is viewed critically. It is considered to be so sensitive that it can be expected that a substance with only low comedogenic activity on rabbit ears will not have any effect on people with healthy skin. However, people with a tendency to acne could be affected. Finished products or mixtures of substances containing comedogenic substances are therefore not necessarily comedogenic themselves.

Individual evidence

  1. ↑ SB Frank: Is the rabbit ear model, in its present state, prophetic of acnegenicity? In: J Am Acad Dermatol. 6 (3), Mar 1982, pp. 373-377. PMID 6461674
  2. ^ OH Mills Jr, AM Kligman: A human model for assessing comedogenic substances. In: Arch Dermatol. 118 (11), Nov 1982, pp. 903-905. PMID 7138047
  3. ↑ ZD Draelos, JC DiNardo: A re-evaluation of the concept comedogenicity. In: J Am Acad Dermatol. 54 (3), Mar 2006, pp. 507-512. PMID 16488305

literature

  • OH Mills, AM Kligman: Acne detergicans. In: Arch Dermatol. (1975) 111 (1), pp. 65-68. PMID 123433
  • JE Fulton Jr, S. Bradley, A. Aqundez, T. Black: Non-comedogenic cosmetics. In: Cutis. 17 (2), Feb 1976, pp. 344-345, 349-351. PMID 138532
  • JE Fulton Jr, SR Pay, JE Fulton: Comedogenicity of current therapeutic products, cosmetics, and ingredients in the rabbit ear. In: J Am Acad Dermatol. 10 (1), 1984, pp. 96-105. PMID 6229554
  • Gerd Plewig , Albert M. Kligman: Acne and Rosacea. 2nd Edition; Springer, 1996, ISBN 3-540-55763-6 .