Landomycins

Landomycin A

Landomycin B

The landomycins belong to the group of angucyclines and are isolated from Streptomyces . They are being studied for use as anti-cancer drugs.

literature

T. Henkel, J. Rohr, JM Beale, and L. Schwenen: Landomycins, new angucycline antibiotics from Streptomyces sp. I. Structural studies on landomycins AD . The Journal of Antibiotics , 1990, 43 (5), pp. 492-503. PMID 2358402 . doi: 10.7164 / antibiotics.43.492 .
OV Tymchyk, BP Matseliukh, VI Lavrinchuk: Sensitivity of Streptomyces globisporus 3-1 - a highly active producer of landomycin E to its own and the other polyketide antibiotics . Mikrobiolohichnyi zhurnal . Volume 66, Number 2, 2004 Mar-Apr, pp. 69-73, PMID 15208856 .
KA Shaaban, S. Srinivasan, R. Kumar, C. Damodaran, J. Rohr: Landomycins PW, cytotoxic angucyclines from Streptomyces cyanogenus S-136 . Journal of Natural Products . Volume 74, number 1, January 2011, pp. 2-11, doi : 10.1021 / np100469y , PMID 21188999 , PMC 3070852 (free full text).
KA Shaaban, C. Stamatkin, C. Damodaran, J. Rohr: 11-Deoxylandomycinone and landomycins XZ, new cytotoxic angucyclin (on) es from a Streptomyces cyanogenus K62 mutant strain . The Journal of Antibiotics . Volume 64, number 1, January 2011, pp. 141–150, doi : 10.1038 / ja.2010.121 , PMID 20978514 , PMC 3030652 (free full text).