Lin-12

Lin-12 is a gene of the Caenorhabditis elegans worm that, together with the glucagon-like peptide 1 (glp-1) gene, codes for the proteins Notch / Lin-12. The gene was discovered while looking for genes whose mutations are responsible for a defective vulva of the worm (the worm is a hermaphrodite). Lin-12 is important for the development of the worm's reproductive organs.

In the Alzheimer -Research Lin-12 is interesting as the protein complex gamma secretase , the Notch / LIN-12 proteolytically cuts, also the section of the amyloid precursor protein mediated.

literature

• I. Greenwald: LIN-12 / Notch signaling: lessons from worms and flies. In: Genes Dev. 1998 Jun 15; 12 (12), pp. 1751-1762. PMID 9637676 (free full text)
• DD Shaye, I. Greenwald: LIN-12 / Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans. In: Development. 2005 Nov; 132 (22), pp. 5081-5092. Epub 2005 Oct 19. PMID 16236769 (free full text)

Web links

• Vulval development. wormbook.org, accessed January 9, 2011 . 
• Protein Summary: LIN-12. wormbase.org, accessed January 9, 2011 .