Lipohyalinosis

Lipohyalinosis is a pathological process on the vessel walls of small perforating arteries and arterioles of the brain. The term is used synonymously with “fibrinoid necrosis”. Fibrinoid necrosis results from the entry of plasma proteins into the vessel wall and is more common in individuals with high blood pressure than in those with normal blood pressure. It can close the affected vessel and cause a lacunar infarct . The term "lipohyalinosis" was coined by Charles Miller Fisher , but the term "fibrinoid necrosis" describes the underlying pathological changes more precisely.

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• Fisher CM (1971) Pathological observations in hypertensive cerebral hemorrhage. In: J Neuropathol Exp Neurol , 30: 536-550. PMID 4105427 ( doi : 10.1097 / 00005072-197107000-00015 ; only for subscribers.)
• Rosenblum WI. Fibrinoid necrosis of small brain arteries and arterioles and military aneurysms as causes of hypertensive hemorrhage: a critical reappraisal. In: Acta Neuropathol , 2008 Jul 19 PMID 18642006