Lynen cycle

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The Lynen cycle (Syn. HMG-CoA cycle ) named after the German biochemist Feodor Lynen (1911–1979) is the metabolic pathway responsible for the biosynthesis of ketone bodies . It occurs when there is a lack of glucose and glycogen .

Course of the Lynen cycle

In the first step, one molecule of acetoacetate is formed from two molecules of acetyl-CoA . At the same time, 2 molecules of coenzyme A are recovered in the reaction. As a next step, β-hydroxybutyrate dehydrogenase (NAD + -dependent) reduces most of the acetoacetate to β-hydroxybutyrate. The Lynen cycle takes place exclusively in the mitochondria of the liver.

Ketone bodies

  • Acetoacetate, 3-hydroxybutyrate, acetone

Individual evidence

  1. ↑ Lovers GM: Ketogenic diet for the treatment of drug-resistant epilepsies and metabolic defects in childhood , 2003, pdf .
  2. ^ Karlson P., ea: Karlsons Biochemie und Pathobiochemie , Georg Thieme Verlag, 2005, p. 282, ISBN 3-13-357815-4 , ( limited preview in Google book search).