Lysophosphatides

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Lysophosphatides or lysophospholipids are esters of phosphoric acid with acylglycerols and the like. a. that have a free hydroxyl group near the phosphate group . They belong to the phospholipids group and have one less acyl group than most phospholipids.

Biologically important compounds of this group are sphingosine-1-phosphate , lysophosphatidylinositol , lysophosphatidic acid ( lysophosphatidic acid , LPA) and lysophosphatidylcholine (LPC). These compounds are of great and extremely complex importance for intracellular signal transduction as well as extracellular signal transmission.

There are five different receptors for sphingosine-1-phosphate in humans (S1P1-5). S1P1 agonists represent a new class of immunosuppressants .

literature

  • J. Chun, EJ Goetzl, T. Hla, Y. Igarashi, KR Lynch, W. Moolenaar, S. Pyne, G. Tigyi: International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature. In: Pharmacological Reviews 54, pp. 265–269 (2002)