Malaise ( French for "discomfort", "malaise") is the family name of the following people:
- Ferdinand von Malaisé (1806-1892), Bavarian major general and educator of King Ludwig III.
- Karl von Malaisé (1868–1946), German major general
- René Malaise (1892–1978), Swedish entomologist and travel writer
Malaise (also Maleizen ) is also the French name of a district of the Belgian city of Overijse .