Menke nitriding

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In chemistry, Menke nitration is a nitration reaction of an aromatic (R = H, alkyl, OH, NH 2 etc.) with copper (II) nitrate [(Cu (NO 3 ) 2 ] and acetic anhydride (Ac 2 O). A nitro group (NO 2 ) is preferably introduced in the ortho position to the electron donor on the aromatic compound.The reaction is named after its discoverer, the Dutch chemist Jean Baptiste Menke (1887–1955).

Frameless


The particularly high ortho selectivity of the Menke nitration is remarkable .

Individual evidence

  1. ^ Zerong Wang: Comprehensive organic name reactions and reagents . John Wiley, Hoboken, NJ 2009, ISBN 978-0-470-63885-9 , doi : 10.1002 / 9780470638859.conrr42 .
  2. ↑ JB Menke: Nitriding with nitrates . In: Recueil des Travaux Chimiques des Pays-Bas . tape 44 , no. 2 , 1925, p. 141 , doi : 10.1002 / recl.19250440209 .