Minimal bactericidal concentration

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In bacteriology, the minimum bactericidal concentration (MBK) defines the concentration of an antibiotic at which 99.9% of the pathogens can be killed within a fixed period of time .

In addition to the minimum inhibitory concentration (MIC), the MTC serves as a parameter for the effectiveness of an antibiotic as well as for assessing the resistance of a pathogen. It is usually determined by diluting the antibiotic in log2 steps in a liquid nutrient medium and is expressed in micrograms per milliliter (µg / ml).

While the MIC can in principle be determined for any antibiotic, the MBK is only useful for those that can develop not only an inhibitory but also a killing ( bactericidal ) effect. These are, for example, aminoglycosides , gyrase inhibitors , penicillins .