NOSPECS classification

The NOSPECS classification is one of two common schemes for documenting the course and stage of the disease in endocrine orbitopathy . It was developed by the American Thyroid Association and has been used since 1969. The sequence of letters is an abbreviation ( acronym ) for the English names of the queried symptoms. The scheme is also known as the Werner classification under the name of its developer, the US doctor Sidney C. Werner .

Within this classification there is an additional classification according to the severity levels 0, A, B and C, with which a certain point value can be determined. Together with another parameter for disease activity , the so-called CAS score (according to Mourits ), the entire course of the disease is assessed.

Before and during treatment, the NOSPECS scheme is an important aid in assessing the progression or therapy-related improvement of the clinical picture and provides an overview of the importance of important symptoms. Nevertheless, its classification is considered less meaningful and useful compared to the so-called LEMO classification , which is an extension of the NOSPECS classification.

class	clinical features	English name
0	no signs or symptoms	N o signs or symptoms
1	Signs (e.g. eyelid retraction), not symptoms	O nly signs, no symptoms
2	Soft tissue involvement	S often tissue involvement
3	Exophthalmos	P roptosis
4th	Muscle changes	E xtraocular muscle involvement
5	Corneal complications	C orneal involvement
6th	Visual and visual field restrictions	S ight loss

Web links

Announcement by the German Society for Endocrinology, Volume 27 - Issue 2/2003 (PDF; 1.3 MB)

Individual evidence

^ Albert J. Augustin: Ophthalmology. 3rd, completely revised and expanded edition. Springer, Berlin et al. 2007, ISBN 978-3-540-30454-8 , pp. 84-85, books.google.de .
↑ KP Boergen, CR Pickardt: New classification of endocrine orbitopathy. In: The Medical World. Vol. 42, 1991, ISSN 0025-8512 , pp. 72-76.
↑ N. Ardjomand, Gertrud Esche, Susanne Lindner, Manuela Panzitt, Reingard Aigner, Andrea Berghold, Andrea Langmann: The importance of octreotid scintigraphy in the diagnosis of active endocrine orbitopathy. In: Spectrum of Ophthalmology. Vol. 15, No. 3, June 2001, ISSN 0930-4282 , pp. 113-116, doi : 10.1007 / BF03162928 .
↑ Georg J. Kahaly, Peter Bumb, Susanne Pitz, Christoph Scheurle, Katharina A. Ponto, Kathrin Lingl, Gerhard Hommel, Wibke Müller-Forell, Matthias M. Weber, Wolf J. Mann: Operative relief for endocrine orbitopathy. In: Medical Clinic. Vol. 102, No. 9, September 2007, ISSN 0723-5003 , pp. 714-719, doi : 10.1007 / s00063-007-1097-1 .
^ A. Eckstein, M. Plicht, N. Morgenthaler, KP Steuhl, K. Renzing-Köhler, B. Quadbeck, K. Mann, J. Esser: The TSH receptor antibodies help to assess the prognosis of an endocrine orbitopathy. 101st annual meeting of the DOG (German Ophthalmological Society) 2003.

[1] Albert J. Augustin: Ophthalmology. 3rd, completely revised and expanded edition. Springer, Berlin et al. 2007, ISBN 978-3-540-30454-8 , pp. 84-85, books.google.de .

[2] KP Boergen, CR Pickardt: New classification of endocrine orbitopathy. In: The Medical World. Vol. 42, 1991, ISSN 0025-8512 , pp. 72-76.

[3] N. Ardjomand, Gertrud Esche, Susanne Lindner, Manuela Panzitt, Reingard Aigner, Andrea Berghold, Andrea Langmann: The importance of octreotid scintigraphy in the diagnosis of active endocrine orbitopathy. In: Spectrum of Ophthalmology. Vol. 15, No. 3, June 2001, ISSN 0930-4282 , pp. 113-116, doi : 10.1007 / BF03162928 .

[4] Georg J. Kahaly, Peter Bumb, Susanne Pitz, Christoph Scheurle, Katharina A. Ponto, Kathrin Lingl, Gerhard Hommel, Wibke Müller-Forell, Matthias M. Weber, Wolf J. Mann: Operative relief for endocrine orbitopathy. In: Medical Clinic. Vol. 102, No. 9, September 2007, ISSN 0723-5003 , pp. 714-719, doi : 10.1007 / s00063-007-1097-1 .

[5] A. Eckstein, M. Plicht, N. Morgenthaler, KP Steuhl, K. Renzing-Köhler, B. Quadbeck, K. Mann, J. Esser: The TSH receptor antibodies help to assess the prognosis of an endocrine orbitopathy. 101st annual meeting of the DOG (German Ophthalmological Society) 2003.