Thin basement membrane type nephropathy

The thin basement membrane disease is (syndrome of thin basement membrane), the most common cause of red blood cells in the urine ( hematuria ) in both children and adults. About 1% of the population are affected. Usually there is also a slightly increased protein excretion in the urine (proteinuria) . The kidney function is usually normal. In the electron microscopic examination of kidney tissue falls within the renal diluting the basement membrane on, an important component of the blood-urine barrier . The disease occurs in families. In around 40% of cases, mutations are found in the same genes that are also changed in the autosomal recessive Alport syndrome . Some cases of thin basement membrane-type nephropathy may be heterozygous carriers of Alport's syndrome.

The course is usually benign; there is usually no loss of kidney function .

If other sources of bleeding in the urinary tract, in particular tumors and urinary stones , have been ruled out by a urological examination , invasive (interventional) diagnostics by means of kidney puncture are only required in the case of atypical courses with high protein concentrations in the urine or impaired kidney function. In terms of differential diagnosis , IgA nephritis or Alport syndrome are primarily considered in these cases .

Treatment of the thin basement membrane type nephropathy is not necessary.

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• Savige J. et al .: Thin basement membrane nephropathy . In: Kidney International . No. 64 , 2003, p. 1169-1178 ( Article ).

Web links

• Thin Glomerular Basement Membranes Agnes Fogo Atlas of Renal Pathology Am J Kidney Dis 34 (6): E23, 1999

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !