Neurotensin receptor

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3D structural model of the NTS 1 receptor based on X-ray crystal structure  analysis data according to PDB 4GRV

Neurotensin receptors ( NTS receptors for short ) are proteins to which the neuropeptide neurotensin binds for the purpose of signal transmission. Among the neurotensin include the NTS 1 - and the NTS 2 receptor and sortilin 1 (NTS 3 receptor). They represent a structurally heterogeneous protein family. While the NTS 1 and NTS 2 receptors belong to the G-protein-coupled receptors , Sortilin 1 is a Vps10p domain receptor . The neurotensin receptors are involved in the regulatory effect of neurotensin on hormone release, the regulation of the dopaminergic system and gastrointestinal activity.

NTS 1 NTS 2 Sortilin 1
genetics
Gene name NTSR1 NTSR2 SORT1
Gene locus 20q13 2p25.1 1p21.3-p13.1
protein
UniProt-Bez. P30989 O95665 Q99523
structure 7TM 7TM Vps10p
length 418 amino acids 410 amino acids 831 amino acids
pharmacology
Signal transduction G q >> G s , G i / o various
function Regulation of the release of prolactin and luteinizing hormone.
Regulation of the dopamine system.
Smooth muscle contraction.
Analgesia.
Hypothermia 		analgesia Internalization
Agonists Neurotensin
Neuromedin N 		Neurotensin
β-lactotensin
Levocabastine 		Neurotensin
Antagonists SR-48692 Neurotensin
levocabastine

Individual evidence

  1. ↑ Morinville A. et al. : Internalization and trafficking of neurotensin via NTS3 receptors in HT29 cells . In: Int. J Biochem. Cell Biol . 36, No. 11, 2004, pp. 2153-2168. PMID 15313463 .
  2. ↑ a b c d Pelaprat D: Interactions between neurotensin receptors and G proteins . In: Peptides . 27, No. 10, 2006, pp. 2476-2487. PMID 16919370 .

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