Neurotensin receptor
Neurotensin receptors ( NTS receptors for short ) are proteins to which the neuropeptide neurotensin binds for the purpose of signal transmission. Among the neurotensin include the NTS 1 - and the NTS 2 receptor and sortilin 1 (NTS 3 receptor). They represent a structurally heterogeneous protein family. While the NTS 1 and NTS 2 receptors belong to the G-protein-coupled receptors , Sortilin 1 is a Vps10p domain receptor . The neurotensin receptors are involved in the regulatory effect of neurotensin on hormone release, the regulation of the dopaminergic system and gastrointestinal activity.
NTS 1 | NTS 2 | Sortilin 1 | |
---|---|---|---|
genetics | |||
Gene name | NTSR1 | NTSR2 | SORT1 |
Gene locus | 20q13 | 2p25.1 | 1p21.3-p13.1 |
protein | |||
UniProt-Bez. | P30989 | O95665 | Q99523 |
structure | 7TM | 7TM | Vps10p |
length | 418 amino acids | 410 amino acids | 831 amino acids |
pharmacology | |||
Signal transduction | G q >> G s , G i / o | various | |
function | Regulation of the release of prolactin and luteinizing hormone. Regulation of the dopamine system. Smooth muscle contraction. Analgesia. Hypothermia |
analgesia | Internalization |
Agonists | Neurotensin Neuromedin N |
Neurotensin β-lactotensin Levocabastine |
Neurotensin |
Antagonists | SR-48692 | Neurotensin levocabastine |
Individual evidence
- ↑ Morinville A. et al. : Internalization and trafficking of neurotensin via NTS3 receptors in HT29 cells . In: Int. J Biochem. Cell Biol . 36, No. 11, 2004, pp. 2153-2168. PMID 15313463 .
- ↑ a b c d Pelaprat D: Interactions between neurotensin receptors and G proteins . In: Peptides . 27, No. 10, 2006, pp. 2476-2487. PMID 16919370 .
Web links
- IUPHAR Database: Neurotensin receptors: Introduction