Neurotensin

Neurotensin
	Structural formula
	Existing structural data : 3F6K
Properties of human protein
Mass / length primary structure	13 amino acids, 1673 daltons
Precursor	(148 aa)
Identifier
Gene name	NTS
External IDs	OMIM : 162650 ; UniProt : P30990 ; CAS number : 55508-42-4;
Occurrence
Parent taxon	Mammals

Neurotensin is a neuropeptide that is produced in the central nervous system and in the N cells of the small intestine . In the gastrointestinal tract it functions as an intestinal hormone and as such inhibits the acid secretion of the stomach and stimulates the intestinal contraction and glucagon release . Neurotensin has an antipsychotic effect in the brain and is possibly involved in the pathogenesis of schizophrenia .

Neurotensin consists of 13 amino acids :

pyroGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH.

Neurotensin mediates its effects by activating the G-protein-coupled receptors NT ₁ and NT ₂ as well as the NT ₃ receptor.

Individual evidence

↑ Homologues at OMA .
↑ Axel M. Gressner, Torsten Arndt: Lexicon of Medical Laboratory Diagnostics Volume 1: Clinical Chemistry . Springer-Verlag, 2012, ISBN 978-3-540-49520-8 , pp. 957 ( limited preview in Google Book search).

^ ^A ^b Gerhard founder, Otto Benkert: Manual of psychopharmacotherapy . Springer-Verlag, 2011, ISBN 978-3-642-19844-1 , p. 199 ( limited preview in Google Book search).

↑ M. Allgöwer, LF Hollender, H.-J. Peiper: Surgical gastroenterology . Springer-Verlag, 2013, ISBN 978-3-662-00618-4 , pp. 131 ( limited preview in Google Book search).

[1] Homologues at OMA .

[Axel_M._Gressner,_Torsten_Arndt-2] Axel M. Gressner, Torsten Arndt: Lexicon of Medical Laboratory Diagnostics Volume 1: Clinical Chemistry . Springer-Verlag, 2012, ISBN 978-3-540-49520-8 , pp. 957 ( limited preview in Google Book search).

[Gerhard_Gründer,_Otto_Benkert-3] A ^b Gerhard founder, Otto Benkert: Manual of psychopharmacotherapy . Springer-Verlag, 2011, ISBN 978-3-642-19844-1 , p. 199 ( limited preview in Google Book search).

[M._Allgöwer,_L._F._Hollender,_H.-J._Peiper-4] M. Allgöwer, LF Hollender, H.-J. Peiper: Surgical gastroenterology . Springer-Verlag, 2013, ISBN 978-3-662-00618-4 , pp. 131 ( limited preview in Google Book search).