Nucleofugy

The Nukleofugie ( Greek nucleos = core phyge is left =) in the Chemistry a measure of the ability of an atom to secede from a molecule while a free pair of electrons to take, which previously passed through a covalent bond was bound. Typical nucleofuges are often negatively charged after cleavage, have a strongly negative partial charge or have a free electron pair in a relatively high- energy atomic orbital .

A nucleofug is a special leaving group .

Examples of nucleofuge

• Halides
• Alcohols
• water

Estimation of the nucleofugy

The nucleofugacy can be estimated well from the base strength of a molecule. The more basic the leaving group, the worse it is. Weak bases, i.e. bases of strong conjugated acids , are therefore good leaving groups.

The following list shows some nucleofuges in order of decreasing quality:

H ₂ O> I ^- > Br ^- > Cl ^- > F ^- > OH ^- > NH ₂ ^-

Reactions that generate nucleofuges

• Nucleophilic substitution
• Elimination reactions
• Addition-elimination reactions

See also

• Nucleophilicity

Individual evidence

1. ^ Streiter, André: Electrofugacy and electrophilicity of acceptor-substituted benzhydryl systems. Ed .: LMU Munich: Faculty of Chemistry and Pharmacy. 2006.
2. ↑ ChemLearning - Allgemeine Chemie OC II. Accessed February 11, 2020 .