PNMA family
The PNMA family is a family of proteins . The abbreviation “PNMA” stands for paraneoplastic antigen Ma .
classification
| Name of the gene | Name of the protein | chromosome |
|---|---|---|
| PNMA1 | Paraneoplastic antigen Ma1 | 14q24.3 |
| PNMA2 | Paraneoplastic antigen Ma2 | 8p21.1 |
| PNMA3 | Paraneoplastic antigen Ma3 | Xq28 |
| PNMA4 (MOAP1) | Paraneoplastic antigen Ma4 (modulator of apoptosis 1) | 14q32.12 |
| PNMA5 | Paraneoplastic antigen Ma5 | Xq28 |
| PNMA6A | Paraneoplastic antigen-like protein 6A | Xq28 |
| PNMA6B | Paraneoplastic antigen-like protein 6B | Xq28 |
| PNMA6C | Paraneoplastic antigen-like protein 6C | Xq28 |
| PNMA6D | Paraneoplastic antigen-like protein 6D | Xq28 |
| PNMAL1 | PNMA-like protein | 19q13.32 |
| PNMAL2 | PNMA-like protein | 19q13.32 |
properties
The function of the PNMA proteins is still largely unknown with one exception. PNMA4 (MOAP1) can induce programmed cell death (apoptosis) in connection with the protein Bax . Because of the homologies, a similar function is ascribed to the other members of the family. Some paraneoplastic syndromes are associated with antibodies directed against certain PNMA proteins. In anti-Ma2-associated encephalitis , for example, these are antibodies against PNMA2 .
further reading
- M. Schüller, D. Jenne, R. Voltz: The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease. In: Journal of neuroimmunology. Volume 169, Number 1-2, December 2005, pp 172-176, ISSN 0165-5728 . doi : 10.1016 / j.jneuro in 2005.08.019 . PMID 16214224 .
Individual evidence
- ↑ UniProt Q8ND90 , last accessed on February 17, 2012
- ↑ UniProt Q9UL42 , last accessed on February 17, 2012
- ↑ UniProt Q9UL41 , last accessed on February 17, 2012
- ↑ UniProt Q96BY2 , last accessed on February 17, 2012
- ↑ UniProt Q96PV4 , last accessed on February 17, 2012
- ↑ UniProt P0CW24 , last accessed on February 17, 2012
- ↑ UniProt P0C5W0 , last accessed on February 17, 2012
- ↑ UniProt P0CW26 , last accessed on February 17, 2012
- ↑ UniProt P0CZ20 , last accessed on February 17, 2012
- ↑ a b UniProt Q86V59 , last accessed on February 17, 2012
- ↑ Robert B. Darnell, Jerome B. Posner: Paraneoplastic Syndromes Oxford Univ. Pr., 2011, ISBN 978-0199772735 , p. 326
- ↑ J. Dalmau, F. Graus, A. Villarejo, JB Posner, D. Blumenthal, B. Thiessen, A. Saiz, P. Meneses, MR Rosenfeld: Clinical analysis of anti-Ma2-associated encephalitis. In: Brain: a journal of neurology. Volume 127, Pt 8 August 2004, pp. 1831-1844, ISSN 1460-2156 . doi : 10.1093 / brain / awh203 . PMID 15215214 .
- ↑ MR Rosenfeld, JG Eichen u. a .: Molecular and clinical diversity in paraneoplastic immunity to Ma proteins. In: Annals of neurology. Volume 50, Number 3, September 2001, pp. 339-348, ISSN 0364-5134 . PMID 11558790 .