Paraneoplastic antigen Ma2
| Paraneoplastic antigen Ma2 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 41.5 kilodaltoans / 364 amino acids | |
| Identifier | ||
| Gene name | PNMA2 | |
| External IDs | ||
| Orthologue | ||
| human | House mouse | |
| Entrez | 10687 | 239157 |
| Ensemble | ENSG00000240694 | ENSMUSG00000046204 |
| UniProt | Q9UL42 | Q8BHK0 |
| Refseq (mRNA) | NM_007257 | NM_175498 |
| Refseq (protein) | NP_009188 | NP_780707 |
| Gene locus | Chr 8: 26.5 - 26.51 Mb | Chr 14: 66.91 - 66.92 Mb |
| PubMed search | 10687 |
239157
|
The paraneoplastic antigen Ma2 ( PNMA2 ) is a protein with an unknown function. Participation in programmed cell death (apoptosis) is suspected. The protein is by the same PNMA2 gene encoding that in humans on the short arm of chromosome 8 is located (8p21). The paraneoplastic antigen Ma2 belongs to the PNMA family .
It is made naturally in the brain . It is also made by certain cancer cells, mostly cancer cells in testicular cancer .
Medical importance
Some neurological diseases are antibodies in both the cerebrospinal fluid (CSF) and in the blood serum detectable directed against the paraneoplastic antigen M a2. The diseases are paraneoplastic syndromes , especially testicular cancer: limbic encephalitis and brainstem encephalitis . Signs of the two diseases can occur in parallel and are summarized as anti-Ma2-associated encephalitis .
further reading
- R. Voltz, SH Gultekin et al. a .: A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer. In: The New England Journal of Medicine . Volume 340, Number 23, June 1999, pp. 1788-1795, ISSN 0028-4793 . doi : 10.1056 / NEJM199906103402303 . PMID 10362822 .
- M. Schüller, D. Jenne, R. Voltz: The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease. In: Journal of neuroimmunology. Volume 169, Number 1-2, December 2005, pp 172-176, ISSN 0165-5728 . doi : 10.1016 / j.jneuro in 2005.08.019 . PMID 16214224 .
- T. Cui, M. Hurtig et al. a .: Paraneoplastic antigen Ma2 autoantibodies as specific blood biomarkers for detection of early recurrence of small intestine neuroendocrine tumors. In: PloS one. Volume 5, Number 12, 2010, p. E16010, ISSN 1932-6203 . doi : 10.1371 / journal.pone.0016010 . PMID 21209860 . PMC 3012732 (free full text).
Individual evidence
- ↑ a b Robert B. Darnell, Jerome B. Posner: Paraneoplastic Syndromes Oxford Univ. Pr., 2011, ISBN 978-0199772735 , p. 326
- ↑ Entry PNMA2 in the HGNC database, last accessed on February 18, 2012.
Web links
- Paraneoplastic antigen Ma2. In: Online Mendelian Inheritance in Man . (english) (english)
- UniProt Q9UL42