Chromosome 8 (human)

Human chromosome 8 idiogram

Chromosome 8 is one of 23 chromosomes pairs of people . A normal person has two largely identical copies of this chromosome in most of his cells .

Decoding the chromosome 8

Chromosome 8 consists of 146 million base pairs . A base pair is the smallest unit of information in DNA . Chromosome 8 contains between 4.5 and 5% of the total DNA of a human cell. Identifying the genes on this chromosome is part of an ongoing process of deciphering the human genome. There are between 700 and 1100 genes on chromosome 8. So far 743 of them are known.

Known genes on chromosome 8

Chromosome 8 contains the following genes, among others:

• GnRH1 : gonadoliberin
• DNM1, DNM2, DNM3 : Dynamine
• t-PA : tissue-specific plasminogen activator
• TG : thyroglobulin
• LPL : lipoprotein lipase

Medical importance

The 46 human chromosomes

The genes on chromosome 8 are associated with the following genetic diseases or symptoms . These are among others:

• Burkitt lymphoma
• Corpus callosum agenesis
• Diamond Blackfan Syndrome
• Hereditary spherocytosis (ball cell anemia)
• Multiple cartilaginous exostoses
• Nijmegen Breakage Syndrome
• Pfeiffer syndrome
• Rothmund-Thompson Syndrome
• Trisomy 8 (Warkany Syndrome 2)
• Waardenburg syndrome
• Werner syndrome

Individual evidence

1. ↑ Genetics Home Reference, Chromosome 8 , as of February 29, 2008
2. ↑ ensembl.org, Chromosome 8 , accessed March 13, 2008
3. ↑ Genetics Home Reference, Conditions related to genes on chromosome 8. , As of February 29, 2008

literature

• C. Nusbaum et al. a .: DNA sequence and analysis of human chromosome 8. In: Nature . 439/2006, pp. 331-5, PMID 16421571
• F. Gilbert: Chromosome 8. In: Genet. Test. 5/2001, pp. 345-54, PMID 11960583

Web links

• Ensembl - Chromosome 8 (English)
• Genetics Home Reference - Chromosome 8 (English)
• The "gene map" of chromosome 8 (English)