Chromosome 6 (human)

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Human chromosome 6 idiogram

Chromosome 6 is one of 23 pairs of chromosomes in humans . In general, humans have two largely identical copies of this chromosome in almost all cells .

Decryption

Chromosome 6 consists of 171 million base pairs , the smallest information units in DNA . This chromosome contains approximately 5.5% of the total DNA in a human cell. It contains between 1,100 and 1,600 genes , the identification of which is part of an ongoing process to decipher the human genome.

Known genes

  • CNR1 : cannabinoid receptor 1
  • Factor XIII : fibrin stabilizing factor
  • HSPA1A : Hsp70
  • CDKN1A : p21
  • DSP : Desmoplakin
  • CYP21 : steroid 21 hydroxylase
  • PARCK : Parkin ubiquitin protein ligase
  • PKHD1 : Polycystic kidney and hepatic disease 1
  • PLG : plasmin
  • HFE : Hereditary Hemochromatosis Protein
  • VEGF : Vascular Endothelial Growth Factor
  • MUT : methylmalonyl-CoA mutase
  • MHC / HLA : Major Histocompatibility Complex / Human Leukocyte Antigen
  • PARK2 : Parkin ubiquitin protein ligase

Phenotypic characteristics

The 46 human chromosomes

The genes on chromosome 6 are associated with the following genetically determined symptoms or even diseases . These are among others:

Individual evidence

  1. ↑ Genetics Home Reference, Chromosome 6 , as of February 29, 2008
  2. ↑ Genetics Home Reference, Conditions related to genes on chromosome 6. , As of February 29, 2008

literature

  • AJ Mungall et al. a .: The DNA sequence and analysis of human chromosome 6. In: Nature . 425/2003, pp. 805-11, PMID 14574404
  • F. Gilbert: Chromosome 6. In: Genet. Test. 6/2002, pp. 341-58, PMID 12537662

Web links