Desmoplakin
| DSP | ||
|---|---|---|
| other names |
Desmoplakin; 250/210 KDa Paraneoplastic Pemphigus Antigen; DP; Desmoplakin (DPI, DPII); Desmoplakin II; Desmoplakin I; DCWHKTA; KPPS2; PPKS2; DPII; DPI |
|
| Properties of human protein | ||
| Mass / length primary structure | 2871 amino acids, 331774 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue | ||
| human | House mouse | |
| Entrez | 1832 | 109620 |
| Ensemble | ENSG00000096696 | ENSMUSG00000054889 |
| UniProt | P15924 | E9Q557 |
| Refseq (mRNA) | NM_001008844 | NM_023842 |
| Refseq (protein) | NP_001008844 | NP_076331 |
| Gene locus | Chr 6: 7.54 - 7.59 Mb | Chr 13: 38.15 - 38.2 Mb |
| PubMed search | 1832 |
109620
|
Desmoplakin is a protein found in desmosomes .
properties
Desmoplakin is a component of desmosomal plaques . With the help of the anchor proteins plakoglobin and plakophilin, it establishes the connection between intermediate filaments and the proteins of the cell contact. These are e.g. B. Keratin filaments in epithelial tissues or desmin in heart tissue with the transmembrane proteins desmoglein and desmocollin of the cadherin family. This connects the cytoskeleton with the cell-cell contacts.
Individual evidence
- ^ E. Delva, DK Tucker, AP Kowalczyk: The desmosome. In: Cold Spring Harbor perspectives in biology. Volume 1, Number 2, August 2009, p. A002543, ISSN 1943-0264 . doi : 10.1101 / cshperspect.a002543 . PMID 20066089 . PMC 2742091 (free full text).
- ↑ JG Boyer, MA Bernstein, C. Boudreau-Larivière: Plakins in striated muscle. In: Muscle & nerve. Volume 41, Number 3, March 2010, pp. 299-308, ISSN 1097-4598 . doi : 10.1002 / mus.21472 . PMID 19768769 .
- ↑ C. Al-Jassar, H. Bikker, M. Overduin, M. Chidgey: Mechanistic basis of desmosome-targeted diseases. In: Journal of molecular biology. Volume 425, Number 21, November 2013, pp. 4006-4022, ISSN 1089-8638 . doi : 10.1016 / j.jmb.2013.07.035 . PMID 23911551 . PMC 3807649 (free full text).