Chromosome 9 (human)

Human chromosome 9 idiogram

Chromosome 9 is one of 23 chromosomes pairs of people . A normal person has two largely identical copies of this chromosome in most of his cells .

Decoding the chromosome 9

Chromosome 9 consists of 140 million base pairs . A base pair is the smallest unit of information in DNA . Chromosome 9 contains about 4.5% of the total DNA of a human cell. Identifying the genes on this chromosome is part of an ongoing process of deciphering the human genome. There are between 800 and 1300 genes on chromosome 9. So far 904 of them are known.

Known genes on chromosome 9

Chromosome 9 contains the following genes, among others:

• COX-1 : cyclooxygenase-1
• FRDA : Frataxin
• Flavokinase
• Glycodelin
• BNC2
• STOM : stomatin
• ALDOB: Aldolase B

Medical importance

The 46 human chromosomes

The genes on chromosome 9 are associated with the following genetically determined diseases or symptoms :

• Amyotrophic Lateral Sclerosis
• Bladder cancer
• Borderline personality disorder
• Ehlers-Danlos Syndrome
• Friedreich's ataxia
• Galactosemia
• Gorlin-Goltz Syndrome
• Geniospasm
• Hereditary fructose intolerance
• Osler's disease
• Neuroacanthocytosis
• Oculocutaneous albinism type 3
• Osteoonychodysplasia
• Pleomorphic xanthoastrocytoma
• familial thrombotic thrombocytopenic purpura
• Tuberous sclerosis

Philadelphia chromosome

See main article Philadelphia Chromosome

The Philadelphia chromosome (Ph1; t (9; 22) (q34; q11)) is a chromosome change in which a shortened chromosome 22 is created through a translocation (exchange) with a chromosome section of chromosome 9. Historically, this was the first chromosomal change that could be linked to the development of cancer .

Trisomy 9 (Rethoré syndrome)

See main article Trisomy 9

When Rethoré syndrome (trisomy 9) a tripling of chromosome 9 by a is in many body cells genome mutation before.

Individual evidence

1. ↑ Genetics Home Reference, Chromosome 9 , as of February 29, 2008
2. ↑ ensembl.org, Chromosome 9 , accessed March 13, 2008
3. ↑ Genetics Home Reference, Conditions related to genes on chromosome 9. , As of February 29, 2008
4. ↑ thistle, MA, Hottenga, JJ, Trull, TJ & Boomsma, DI (2008). Chromosomes 9: linkage for borderline personality disorder features. Psychiatric Genetics, 18 (6), 302-307.

literature

• SJ Humphray et al: DNA sequence and analysis of human chromosome 9. In: Nature . 429/2004, pp. 369-74, PMID 15164053
• F. Gilbert F, N. Kauff: Disease genes and chromosomes: disease maps of the human genome. Chromosome 9. In: Genet Test , 5/2001, pp. 157-74, PMID 11551106
• R. Kurzrock and others: Philadelphia chromosome-positive leukemias: from basic mechanisms to molecular therapeutics. In: Ann Intern Med , 138/2003, pp. 819-30, PMID 12755554

Web links

• Ensembl - Chromosome 9 (English)
• Genetics Home Reference - chromosome 9 (English)
• The "gene map" of chromosome 9 (English)