Chromosome 10 (human)

Human chromosome 10 idiogram

Chromosome 10 is one of 23 chromosomes pairs of people . A normal person has two largely identical copies of this chromosome in most of his cells .

Decoding of chromosome 10

Chromosome 10 consists of 135 million base pairs . A base pair is the smallest unit of information in DNA . Chromosome 10 contains about 4 to 4.5% of the total DNA of a human cell . Identifying the genes on this chromosome is part of an ongoing process of deciphering the human genome. There are up to 1200 genes on chromosome 10. So far, 819 of them are known.

Known genes on chromosome 10

Chromosome 10 contains the following genes, among others:

• KISS1 : KiSS1 receptor
• FGF-8 : fibroblast growth factor 8
• PTEN : Phosphatase and Tensin homolog

Medical importance

The 46 human chromosomes.

The genes on chromosome 10 are associated with the following genetically determined diseases or symptoms :

• Apert syndrome
• Cowden Syndrome
• Crouzon's syndrome
• Jackson-Weiss Syndrome
• Günther's disease
• Multiple endocrine neoplasia MEN2
• Trisomy 10
• Usher Syndrome
• Wolman disease

Individual evidence

1. ↑ Genetics Home Reference, Chromosome 10 , as of February 29, 2008
2. ↑ ensembl.org, Chromosome 10 , accessed March 13, 2008
3. ↑ Genetics Home Reference, Conditions related to genes on chromosome 10. , As of February 29, 2008

literature

• P. Deloukas et al: The DNA sequence and comparative analysis of human chromosome 10. In: Nature , 429/2004 pp. 375-81. PMID 15164054
• P. Deloukas et al .: Report of the third international workshop on human chromosome 10 mapping and sequencing 1999. In: Cytogenet Cell Genet , 90/2000, pp. 1-12. PMID 11060438
• F. Gilbert: Chromosome 10. In: Genet Test , 5/2001, pp. 69-82. PMID 11336406

Web links

• Ensembl - Chromosome 10 (English)
• Genetics Home Reference - chromosome 10 (English)
• The "gene map" of chromosome 10 (English)