KiSS1 receptor

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KISS1 receptor
Properties of human protein
Identifier
Gene names KISS1R  ; AXOR12; GPR54; HOT7T175
External IDs
Drug information
Drug class hormone
Occurrence
Parent taxon Bilateria (bilateral animals)
Orthologue
human mouse
Entrez 84634 114229
Ensemble ENSG00000116014 ENSMUSG00000035773
UniProt Q969F8 Q91V45
Refseq (mRNA) NM_032551 NM_053244
Refseq (protein) NP_115940 NP_444474
Gene locus Chr 19: 0.87 - 0.87 Mb Chr 10: 79.32 - 79.33 Mb
PubMed search 84634 114229

The KiSS1 receptor (formerly also GPR54 , English also KiSS1-derived peptide receptor ) is a G-protein-coupled receptor that binds the peptide hormone kisspeptin .

function

The KiSS1 receptor, a G-protein coupled receptor of the galanin type, is the gene product of the KiSS1R gene (also known as the GPR 54 gene). The protein binds the peptide hormone kisspeptin , which is encoded by the gene KiSS1 . The distribution of the gene product in the tissue suggests that it is involved in the regulation of hormonal functions. This assumption is supported by evidence of a role in inducing puberty .

Puberty gene

KiSS1R is also known as the puberty gene. It was discovered while examining an extended family from Saudi Arabia , whose members had an above-average rate of idiopathic hypogonadotropic hypogonadism (IHH). This disease leads to the fact that puberty is completely absent.

According to endocrinologist Stephanie Seminara of Massachusetts General Hospital in Boston , this gene is primarily responsible for activating puberty . Comparable to a switch, this gene activates a cascade of other genes that trigger the typical characteristics of puberty: development of secondary sexual characteristics , hormonal changes, menstruation, etc.

literature

  • Colledge WH: GPR54 and puberty. . In: Trends Endocrinol. Metab. . 15, No. 9, 2005, pp. 448-453. doi : 10.1016 / j.tem.2004.09.008 . PMID 15519892 .
  • Kaiser UB, Kuohung W: KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty . In: Endocrine . 26, No. 3, 2006, pp. 277-284. PMID 16034182 .
  • Seminara SB: Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion . In: Frontiers in Neuroendocrinology . 26, No. 3-4, 2006, pp. 131-138. doi : 10.1016 / j.yfrne.2005.10.001 . PMID 16309735 .
  • Tena-Sempere M: GPR54 and kisspeptin in reproduction . In: Hum. Reprod. Update . 12, No. 5, 2006, pp. 631-639. doi : 10.1093 / humupd / dml023 . PMID 16731583 .
  • Cerrato F, Seminara SB: Human genetics of GPR54. . In: Reviews in endocrine & metabolic disorders . 8, No. 1, 2007, pp. 47-55. doi : 10.1007 / s11154-007-9027-3 . PMID 17334928 .
  • Lee DK, Nguyen T, O'Neill GP, et al. : Discovery of a receptor related to the galanin receptors . In: FEBS Lett . . 446, No. 1, 1999, pp. 103-107. PMID 10100623 .
  • Ohtaki T, Shintani Y, Honda S, et al. : Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor . In: Nature . 411, No. 6837, 2001, pp. 613-617. doi : 10.1038 / 35079135 . PMID 11385580 .
  • Muir AI, Chamberlain L, Elshourbagy NA, et al. : AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. . In: J. Biol. Chem. . 276, No. 31, 2001, pp. 28969-28975. doi : 10.1074 / jbc.M102743200 . PMID 11387329 .
  • Clements MK, McDonald TP, Wang R, et al. : FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. . In: Biochem. Biophys. Res. Commun. . 284, No. 5, 2001, pp. 1189-1193. doi : 10.1006 / bbrc.2001.5098 . PMID 11414709 .
  • Kotani M, Detheux M, Vandenbogaerde A, et al. : The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. . In: J. Biol. Chem. . 276, No. 37, 2001, pp. 34631-34636. doi : 10.1074 / jbc.M104847200 . PMID 11457843 .
  • Hori A, Honda S, Asada M, et al. : Metastin suppresses the motility and growth of CHO cells transfected with its receptor. . In: Biochem. Biophys. Res. Commun. . 286, No. 5, 2001, pp. 958-963. doi : 10.1006 / bbrc.2001.5470 . PMID 11527393 .
  • Ringel MD, Hardy E, Bernet VJ, et al. : Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells. . In: J. Clin. Endocrinol. Metab. . 87, No. 5, 2002, p. 2399. PMID 11994395 .
  • Janneau JL, Maldonado-Estrada J, Tachdjian G, et al. : Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. . In: J. Clin. Endocrinol. Metab. . 87, No. 11, 2002, pp. 5336-5339. PMID 12414911 .
  • Bo-Abbas Y, Acierno JS, Shagoury JK, et al. : Autosomal recessive idiopathic hypogonadotropic hypogonadism: genetic analysis excludes mutations in the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes. . In: J. Clin. Endocrinol. Metab. . 88, No. 6, 2003, pp. 2730-2737. PMID 12788881 .
  • Ikeguchi M, Hirooka Y, Kaibara N: Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. . In: Journal of Cancer Research and Clinical Oncology . 129, No. 9, 2003, pp. 531-535. doi : 10.1007 / s00432-003-0469-z . PMID 12898236 .
  • de Roux N, Genin E, Carel JC, et al. : Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. . In: Proc. Natl. Acad. Sci. USA . 100, No. 19, 2003, pp. 10972-10976. doi : 10.1073 / pnas.1834399100 . PMID 12944565 .
  • Seminara SB, Messager S, Chatzidaki EE, et al. : The GPR54 gene as a regulator of puberty. . In: N. Engl. J. Med. . 349, No. 17, 2003, pp. 1614-1627. doi : 10.1056 / NEJMoa035322 . PMID 14573733 .
  • Ikeguchi M, Yamaguchi K, Kaibara N: Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. . In: Clin. Cancer Res . 10, No. 4, 2004, pp. 1379-1383. PMID 14977840 .
  • Bilban M, Ghaffari-Tabrizi N, Hintermann E, et al. : Kisspeptin-10, a KiSS-1 / metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. . In: J. Cell. Sci. . 117, No. Pt 8, 2004, pp. 1319-1328. doi : 10.1242 / jcs.00971 . PMID 15020672 .
  • Grimwood J, Gordon LA, Olsen A, et al. : The DNA sequence and biology of human chromosome 19 . In: Nature . 428, No. 6982, 2004, pp. 529-535. doi : 10.1038 / nature02399 . PMID 15057824 .

Web links

Individual evidence

  1. ^ Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O'Dowd BF: Discovery of a receptor related to the galanin receptors . In: FEBS Lett. . 446, No. 1, 1999, pp. 103-107. PMID 10100623 .
  2. ↑ Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M: Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor . In: Nature . 411, No. 6837, 2001, pp. 613-617. doi : 10.1038 / 35079135 . PMID 11385580 .
  3. ↑ Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC: AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1 . In: J. Biol. Chem. . 276, No. 31, 2001, pp. 28969-28975. doi : 10.1074 / jbc.M102743200 . PMID 11387329 .
  4. ↑ Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderlösungen JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M: The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54 . In: J. Biol. Chem. . 276, No. 37, 2001, pp. 34631-34636. doi : 10.1074 / jbc.M104847200 . PMID 11457843 .
  5. ↑ Entrez Gene: KISS1R KISS1 receptor . Retrieved January 7, 2011.