Chromosome 15 (human)

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Human chromosome 15 idiogram

The human chromosome 15 is one of 23 chromosomes pairs of people . A normal person has two largely identical copies of this chromosome in most of his cells . Chromosome 15 is an acrocentric chromosome , which means it has a terminal centromere .

Acrocentric-metacentric.svg

Decoding the chromosome 15

Chromosome 15 consists of 100 million base pairs . A base pair is the smallest unit of information in DNA . Chromosome 15 contains about 3 to 3.5% of the total DNA of a human cell . Identifying the genes on this chromosome is part of an ongoing process of deciphering the human genome. There are between 650 and 1000 genes on chromosome 15. So far 634 of them are known.

Known genes on chromosome 15

Chromosome 15 contains the following genes, among others:

Medical importance

The 23 pairs of chromosomes in humans.

The genes on chromosome 15 have been linked to the following genetic diseases or symptoms . These are among others:

Individual evidence

  1. Genetics Home Reference, Chromosome 15 , as of February 29, 2008
  2. ensembl.org, Chromosome 15 , accessed March 18, 2008
  3. Genetics Home Reference, Conditions related to genes on chromosome 15. , As of February 29, 2008
  4. Aegeneaes Syndrome.  In: Online Mendelian Inheritance in Man . (English).

literature

  • MC Zody et al .: Analysis of the DNA sequence and duplication history of human chromosome 15. In: Nature , 440/2006, pp. 671-5. PMID 16572171
  • M. Zollino et al .: Partial duplication of the long arm of chromosome 15: confirmation of a causative role in craniosynostosis and definition of a 15q25-qter trisomy syndrome. In: Am J Med Genet , 87/1999, pp. 391-4. PMID 10594876
  • F. Gilbert: Disease genes and chromosomes: disease maps of the human genome. Chromosome 15. In: Genet Test , 3/1999, pp. 309-22. PMID 10495933

Web links