Chromosome 3 (human)

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Human chromosome 3 idiogram

Chromosome 3 is one of 23 chromosomes pairs of people . A normal person has two largely identical copies of this chromosome in most of his cells .

Decoding the chromosome 3

Chromosome 3 consists of 199 million base pairs . A base pair is the smallest unit of information in DNA . Chromosome 3 contains approximately 6.5% of the total DNA of a human cell . Identifying the genes on this chromosome is part of an ongoing process of deciphering the human genome . There are between 1100 and 1500 genes on chromosome 3. When sequencing in May 2006 1463 protein-coding genes were found. Of these, 505 are associated with a wide variety of diseases. Also the most sensitive part of the human genome, the FHIT gene ( Fragile histidine triad), is located on chromosome 3. This gene is involved in around 50% of all esophageal , stomach and colon cancer diseases.

Known genes on chromosome 3

Chromosome 3 contains the following genes, among others:

Medical importance

The 46 human chromosomes

The following genetically determined or predisposed diseases or symptoms are associated with the genes located on chromosome 3 . These are among others:

Trisomy 3

see main article Trisomy 3

The trisome presence of genetic material from chromosome 3 is called trisomy 3 . A number of different symptoms can arise.

Androgenetic hair loss

The main cause of androgenetic hair loss (hereditary hair loss) is the so-called androgen receptor gene (AR), on the X chromosome . It is now known, however, that other genes have an influence on this normal type of hair loss in men. A working group at the University of Bonn found an area in area q26 on chromosome 3 that is directly related to androgenetic hair loss.

Individual evidence

  1. Genetics Home Reference, Chromosome 3 , as of February 29, 2008
  2. Max Planck Institute for Molecular Genetics, Human chromosome 3 reveals its secrets ( Memento of May 12, 2011 in the Internet Archive ), press release of May 17, 2006
  3. DM Muzny u. a., The DNA sequence, annotation and analysis of human chromosome 3. In: Nature , 440/2006, pp. 1194-8, PMID 16641997
  4. Genetics Home Reference, Conditions related to genes on chromosome 3. , As of February 29, 2008
  5. AM Hillmer et al. a., Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. In: Am J Hum Genet , 77/2005, pp. 140-8, PMID 15902657
  6. AM Hillmer et al. a., Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26. In: Am J Hum Genet , 82/2008, pp. 737-43, PMID 18304493
  7. F. Luerweg, hair loss: " Successful search" on chromosome 3 , Science Information Service, February 21, 2008


  • W. Maat et al. a .: Monosomy of chromosome 3 and an inflammatory phenotype occur together in uveal melanoma. In: Invest Ophthalmol Vis Sci. 49/2008, pp. 505-10, PMID 18234992

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