Androgen receptor
| Androgen receptor | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 919 amino acids | |
| Isoforms | AR-A, AR-B | |
| Identifier | ||
| Gene name | AR | |
| External IDs | ||
| Occurrence | ||
| Homology family | AR | |
| Parent taxon | Vertebrates | |
The androgen receptor (AR) is a steroid receptor in vertebrates that is activated by binding the androgenic steroid hormones testosterone or dihydrotestosterone . As NRS 34, it belongs to the superfamily of nuclear receptors .
The androgen receptor is a transcription factor that is responsible for the development of the male appearance and behavior in men throughout life, especially during the development of the embryo and puberty . Mutations in AR - gene can lead to loss of binding capacity of AR to the androgens or other binding partners, which in turn the cause of several hereditary diseases such as:
The AR gene is located on the X chromosome , that is, women are carriers, in genetic men (who, however, are phenotypically women with complete androgen resistance), the disease breaks out because they only have one X chromosome.
The androgen receptor is produced in most types of tissue in humans. The very different activity is due to a myriad of proteins that act as coactivators or corepressors of the receptor. The Androgen Receptor Mutation Database currently lists 71 such proteins as well as chaperones and other transcription factors that are associated with AR.
See also
Individual evidence
- ↑ UniProt P10275 .
- ↑ androgen receptor. In: Online Mendelian Inheritance in Man . (English).
- ↑ LK gouge: Androgen Receptor-Interacting Proteins (pdf; 1.1 MB)