CDK inhibitor 1
| CDK inhibitor 1 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 163 amino acids | |
| Identifier | ||
| Gene name | CDKN1A | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Mammals | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 1026 | 12575 |
| Ensemble | ENSG00000124762 | ENSMUSG00000023067 |
| UniProt | P38936 | P39689 |
| Refseq (mRNA) | NM_000389 | NM_001111099 |
| Refseq (protein) | NP_000380 | NP_001104569 |
| Gene locus | Chr 6: 36.68 - 36.69 Mb | Chr 17: 29.09 - 29.1 Mb |
| PubMed search | 1026 |
12575
|
The CDK inhibitor 1 (also: p21 ) is an inhibitor of cyclin-dependent kinases ( C yclin d ependent k INASE), the essential for the control of the cell cycle in mammals is. Among other things, p21 suppresses cancer growth .
The gene coding for p21 is located in humans on chromosome 6 gene locus p21.2. p21 is mainly regulated by cells at the level of transcription . Induction of transcription of p21 leads to a standstill of the cell cycle, while inhibition of transcription leads to various effects, which depend on the context. p21 knockout mice develop normally by about 16 months of age. Then they start to develop tumors .
Individual evidence
- ↑ Homologues at OMA
- ^ AL Gartel, SK Radhakrishnan: Lost in transcription: p21 repression, mechanisms, and consequences. In: Cancer Research . Volume 65, Number 10, May 2005, pp. 3980-3985, ISSN 0008-5472 . doi: 10.1158 / 0008-5472.CAN-04-3995 . PMID 15899785 . (Review).
Web links
- Matthews / reactome: Transcriptional activation of p21 by p53 after DNA damage
- Matthews / reactome: Inactivation of Cyclin E: Cdk2 complexes by p27 / p21