Pancreatic star cell
Pancreatic star cells are connective tissue cells which, along with other cell types, are found in the pancreas of mammals. Similar to the Ito cells of the liver , pancreatic star cells have the ability to change from a resting to an activated state.
In the resting state, pancreatic star cells are able to store fat and vitamin A. In the activated state, they acquire myofibroblastic properties by producing actin fibers, which are present inside the cell and enable the cell to migrate , and by producing components of the connective tissue extracellular matrix , in particular collagen fibers , which then move out of the cell into the interstitium will be secreted.
In connection with diseases of the pancreas, there is often a significant increase in the existing connective tissue. Here, pancreatic star cells are assigned an important role as producers of connective tissue fibers. There is also evidence that pancreatic star cells in cancer of the pancreas are involved in creating a favorable growth environment for the actual cancer cells.
Individual evidence
- ↑ MV Apte, PS Haber, TL Applegate, ID Norton, GW McCaughan, MA Korsten, RC Pirola, JS Wilson: Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture . In: Good . tape 43 , no. 1 , June 1, 1998, pp. 128-133 , doi : 10.1136 / good 43.1.128 , PMID 9771417 .
- ↑ C. Timke: Isolation, culture and characterization of fibroblastic cells of the human pancreas . Dissertation 2010
- ↑ MB Omary, A. Lugea, AW Lowe, SJ Pandol: The pancreatic stellate cell: a star on the rise in pancreatic diseases . In: Journal of Clinical Investigation . tape 117 , no. 1 , June 2007, p. 50-59 , doi : 10.1172 / JCI30082 , PMID 17200706 .