Pellucidal marginal degeneration

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Classification according to ICD-10
H18.7 Other corneal deformities
ICD-10 online (WHO version 2019)

The pelluzide edge degeneration (from latin lucidum and degeneratio "degeneration" in Biology and Medicine "decay" of cells, tissues or organs) is a thickness loss minor peripheral (on the edge befindlicher) corneal parts , which are usually characterized by a decrease vision in inversus astigmatism expresses.

Pellucidal marginal degeneration with hydrops and detachment of the Descemet membrane

Synonyms are: Pellucide marginal corneal degeneration; PMD; English Pellucid marginal degeneration; PMCD

The name was coined in 1957 by the ophthalmologist V. Schlaeppi.


The frequency and cause are unknown.

Clinical manifestations

Clinical criteria are:

Differential diagnosis

Mainly the keratoconus is to be distinguished with essential differences also in the treatment.


To this day, there is still no agreement on the best possible treatment, as this disease only occurs very rarely. With glasses it is usually not possible to compensate for the refractive error. Optical rehabilitation is often only possible with special quadrant-specific contact lenses .

However, there is the possibility of inserting a transplant with the help of an operation , the removal ( resection ) of the thinned area or a moon-shaped peripheral corneal transplant .


  • M. Moshirfar, JN Edmonds, NL Behunin, SM Christiansen: Current options in the management of pellucid marginal degeneration. In: Journal of refractive surgery. Volume 30, Number 7, July 2014, pp. 474-485, doi: 10.3928 / 1081597X-20140429-02 , PMID 24816208 (review).
  • WB Lee, HS O'Halloran, HE Grossniklaus: Pellucid marginal degeneration and bilateral corneal perforation: case report and review of the literature. In: Eye & contact lens. Volume 34, Number 4, July 2008, pp. 229-233, doi: 10.1097 / ICL.0b013e318164771b , PMID 18787431 , PMC 2988229 (free full text).

Individual evidence

  1. a b c emedicine
  2. a b
  3. V. Schlaeppi: La dystrophy marginal inférieure pellucide de la cornée. In: Bibliotheca ophthalmologica: supplementa ad ophthalmologica. Vol. 12, No. 47, 1957, pp. 672-677, PMID 13382796 .
  4. AA Al-Torbak: Deep anterior lamellar keratoplasty for pellucid marginal degeneration. In: Saudi journal of ophthalmology: official journal of the Saudi Ophthalmological Society. Volume 27, number 1, January 2013, pp. 11-14, doi: 10.1016 / j.sjopt.2012.04.001 , PMID 23964180 , PMC 3729379 (free full text).