Peptide transporter 1

PepT1 in the apical membrane of epithelial cells in the intestine and kidney

Peptide transporter 1 (PepT1) or SLC15A1 (solute carrier family 15, member 1) is a transport protein in the luminal cell membrane of the epithelial cells in the intestine and kidney of humans. It belongs to the class of SLC transporters and, as a tertiary active symport carrier - with the help of an H ⁺ gradient directed into the cell - absorbs oligopeptides (mainly di- and tripeptides ) from food. In humans, the SLC15A1 gene codes for the synthesis of the protein.

Individual evidence

↑ T. Terada, K. Inui: Recent advances in structural biology of peptide transporters. In: Current topics in membranes. Volume 70, 2012, pp. 257-274, doi : 10.1016 / B978-0-12-394316-3.00008-9 , PMID 23177989 .
↑ S. Silbernagl & A. Despopoulos: Pocket Atlas Physiology . 8th edition, Verlag Thieme, 2012, ISBN 978-3135677088 , p. 272.
↑ Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, Hediger MA, Ganapathy V, Leibach FH: Human intestinal H + / peptide cotransporter. Cloning, functional expression, and chromosomal localization . In: J. Biol. Chem . 270, No. 12, March 1995, pp. 6456-63. doi : 10.1074 / jbc.270.12.6456 . PMID 7896779 .

[1] T. Terada, K. Inui: Recent advances in structural biology of peptide transporters. In: Current topics in membranes. Volume 70, 2012, pp. 257-274, doi : 10.1016 / B978-0-12-394316-3.00008-9 , PMID 23177989 .

[2] S. Silbernagl & A. Despopoulos: Pocket Atlas Physiology . 8th edition, Verlag Thieme, 2012, ISBN 978-3135677088 , p. 272.

[pmid7896779-3] Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, Hediger MA, Ganapathy V, Leibach FH: Human intestinal H + / peptide cotransporter. Cloning, functional expression, and chromosomal localization . In: J. Biol. Chem . 270, No. 12, March 1995, pp. 6456-63. doi : 10.1074 / jbc.270.12.6456 . PMID 7896779 .