SLC transporter

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SLC transporter is a collective term for around 52 families of human transport proteins (so-called carrier or membrane proteins ) with almost 400 genes. Solutes that are transported can be charged and uncharged organic molecules as well as inorganic ions .

The members of the individual families have at least 20 percent homology with one another . The individual families show almost no sequence homology to one another. The admission of a new SLC member is therefore decided on the basis of biological function, not evolutionary development. A more general classification, i.e. a classification that includes more taxa , can be found in the TCDB database . This leads most of the SLC families along with many other families as 2.Ax and is the official classification of the transport proteins supported by the IUBMB . The SLC gene nomenclature system was originally proposed by the Human Genome Organization (HUGO) and is the basis for the official HUGO names of the genes that encode these proteins.

history

As a result of a collaboration between Harvard Medical School and the University of Zurich, since 1999 - organized by Matthias Hediger, Peter Meier-Abt and Heini Murer - conferences have been held that are dedicated to scientific exchange in the field of fasciative and secondary active membrane transporters and the current knowledge about Collect transporter physiology, pathology and pharmacology. In 2004 a special issue arose on these transporters, which appeared in the Pflügers Archive - European Journal of Physiology .

nomenclature

This gene family comprises 50 different families (SLC1-50) with a total of 365 genes so far, each of which code for a specific transport protein. The nomenclature numbers the families from 1 to 50 and then uses alphabetical letters to separate the numbers of the individual transporters from the numbers of the families. A phylogenetic relationship was not taken into account because it is a list of human genes. This is why there is no SLC superfamily listed in the current TCDB classification.

Familys

Individual evidence

  1. Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA: The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins Introduction. Pflugers Arch. 2004 Feb; 447 (5): 465-8. PMID 14624363
  2. Kanai Y, Hediger MA: The glutamate / neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects . In: Pflugers Arch . 447, No. 5, 2004, pp. 469-479. doi : 10.1007 / s00424-003-1146-4 . PMID 14530974 .
  3. Uldry M, Thorens B: The SLC2 family of facilitated hexose and polyol transporters . In: Pflugers Arch . 447, No. 5, 2004, pp. 480-489. doi : 10.1007 / s00424-003-1085-0 . PMID 12750891 .
  4. Palacin M, Kanai Y: The ancillary proteins of HATs: SLC3 family of amino acid transporters . In: Pflugers Arch . 447, No. 5, 2004, pp. 490-494. doi : 10.1007 / s00424-003-1062-7 . PMID 14770309 .
  5. ^ Romero MF, Fulton CM, Boron WF: The SLC4 family of HCO 3 - transporters . In: Pflugers Arch . 447, No. 5, 2004, pp. 490-494. doi : 10.1007 / s00424-003-1180-2 . PMID 14722772 .
  6. ^ Wright EM, Turk E: The sodium / glucose cotransport family SLC5 . In: Pflugers Arch . 447, No. 5, 2004, pp. 510-518. doi : 10.1007 / s00424-003-1063-6 . PMID 14722772 .
  7. ^ Chen NH, Reith ME, Quick MW: Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6 . In: Pflugers Arch . 447, No. 5, 2004, pp. 519-531. doi : 10.1007 / s00424-003-1064-5 . PMID 12719981 .
  8. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y: CATs and HATs: the SLC7 family of amino acid transporters . In: Pflugers Arch . 447, No. 5, 2004, pp. 532-542. doi : 10.1007 / s00424-003-1086-z . PMID 14770310 .
  9. Quednau BD, Nicoll DA, Philipson KD: The sodium / calcium exchanger family-SLC8 . In: Pflugers Arch . 447, No. 5, 2004, pp. 543-548. doi : 10.1007 / s00424-003-1065-4 . PMID 12734757 .
  10. Orlowski J, Grinstein S: Diversity of the mammalian sodium / proton exchanger SLC9 gene family . In: Pflugers Arch . 447, No. 5, 2004, pp. 549-565. doi : 10.1007 / s00424-003-1110-3 . PMID 12845533 .
  11. Hagenbuch B, Dawson P: The sodium bile salt cotransport family SLC10 . In: Pflugers Arch . 447, No. 5, 2004, pp. 566-570. doi : 10.1007 / s00424-003-1130-z . PMID 12851823 .
  12. Mackenzie B, Hediger MA: SLC11 family of H + -coupled metal-ion transporters NRAMP1 and DMT1 . In: Pflugers Arch . 447, No. 5, 2004, pp. 571-579. doi : 10.1007 / s00424-003-1141-9 . PMID 14530973 .
  13. ^ Hebert SC, Mount DB, Gamba G: Molecular physiology of cation-coupled Cl-cotransport: the SLC12 family . In: Pflugers Arch . 447, No. 5, 2004, pp. 580-593. doi : 10.1007 / s00424-003-1066-3 . PMID 12739168 .
  14. Markovich D, Murer H: The SLC13 gene family of sodium sulphate / carboxylate cotransporters . In: Pflugers Arch . 447, No. 5, 2004, pp. 594-602. doi : 10.1007 / s00424-003-1207-8 . PMID 12915942 .
  15. Shayakul C, Hediger MA: The SLC14 gene family of urea transporters . In: Pflugers Arch . 447, No. 5, 2004, pp. 603-609. doi : 10.1007 / s00424-003-1124-x . PMID 12856182 .
  16. Daniel H, Kottra G: The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology . In: Pflugers Arch . 447, No. 5, 2004, pp. 610-618. doi : 10.1007 / s00424-003-1101-4 . PMID 12905028 .
  17. Halestrap AP, Meredith D: The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond . In: Pflugers Arch . 447, No. 5, 2004, pp. 619-628. doi : 10.1007 / s00424-003-1067-2 . PMID 12739169 .
  18. ^ Reimer RJ, Edwards RH: Organic anion transport is the primary function of the SLC17 / type I phosphate transporter family . In: Pflugers Arch . 447, No. 5, 2004, pp. 629-635. doi : 10.1007 / s00424-003-1087-y . PMID 12811560 .
  19. Eiden LE, Schafer MK, Weihe E, Schutz B: The vesicular amine transporter family (SLC18): amine / proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine . In: Pflugers Arch . 447, No. 5, 2004, pp. 636-640. doi : 10.1007 / s00424-003-1100-5 . PMID 12827358 .
  20. ^ Ganapathy V, Smith SB, Prasad PD: SLC19: the folate / thiamine transporter family . In: Pflugers Arch . 447, No. 5, 2004, pp. 641-646. doi : 10.1007 / s00424-003-1068-1 . PMID 14770311 .
  21. Collins JF, Bai L, Ghishan FK: The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors . In: Pflugers Arch . 447, No. 5, 2004, pp. 641-646. doi : 10.1007 / s00424-003-1088-x . PMID 12759754 .
  22. Hagenbuch B, Meier PJ: Organic anion transporting polypeptides of the OATP / SLC21 family: phylogenetic classification as OATP / SLCO superfamily, new nomenclature and molecular / functional properties . In: Pflugers Arch . 447, No. 5, 2004, pp. 653-665. doi : 10.1007 / s00424-003-1168-y . PMID 14579113 .
  23. Koepsell H, H Endou: The SLC22 drug transporter family . In: Pflugers Arch . 447, No. 5, 2004, pp. 666-676. doi : 10.1007 / s00424-003-1089-9 . PMID 12883891 .
  24. Takanaga H, Mackenzie B, Hediger MA: Sodium-dependent ascorbic acid transporter family SLC23 . In: Pflugers Arch . 447, No. 5, 2004, pp. 677-682. doi : 10.1007 / s00424-003-1104-1 . PMID 12845532 .
  25. Schnetkamp PP: The SLC24 Na + / Ca2 + -K + exchanger family: vision and beyond . In: Pflugers Arch . 447, No. 5, 2004, pp. 683-688. doi : 10.1007 / s00424-003-1069-0 . PMID 14770312 .
  26. Palmieri F: The mitochondrial transporter family (SLC25): physiological and pathological implications . In: Pflugers Arch . 447, No. 5, 2004, pp. 689-709. doi : 10.1007 / s00424-003-1099-7 . PMID 14598172 .
  27. ^ Mount DB, Romero MF: The SLC26 gene family of multifunctional anion exchangers . In: Pflugers Arch . 447, No. 5, 2004, pp. 710-721. doi : 10.1007 / s00424-003-1090-3 . PMID 12759755 .
  28. Stahl A: A current review of fatty acid transport proteins (SLC27) . In: Pflugers Arch . 447, No. 5, 2004, pp. 722-727. doi : 10.1007 / s00424-003-1106-z . PMID 12856180 .
  29. Gray JH, Owen RP, Giacomini KM: The concentrative nucleoside transporter family, SLC28 . In: Pflugers Arch . 447, No. 5, 2004, pp. 728-734. doi : 10.1007 / s00424-003-1107-y . PMID 12856181 .
  30. Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD: The equilibrative nucleoside transporter family, SLC29 . In: Pflugers Arch . 447, No. 5, 2004, pp. 735-743. doi : 10.1007 / s00424-003-1103-2 . PMID 12838422 .
  31. Palmiter RD, Huang L: Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers . In: Pflugers Arch . 447, No. 5, 2004, pp. 744-751. doi : 10.1007 / s00424-003-1070-7 . PMID 12748859 .
  32. Petris MJ: The SLC31 (Ctr) copper transporter family . In: Pflugers Arch . 447, No. 5, 2004, pp. 752-755. doi : 10.1007 / s00424-003-1092-1 . PMID 12827356 .
  33. Gasnier B: The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids . In: Pflugers Arch . 447, No. 5, 2004, pp. 752-755. doi : 10.1007 / s00424-003-1091-2 . PMID 12750892 .
  34. Hirabayashi Y, Kanamori A, Nomura KH, Nomura K: The acetyl-CoA transporter family SLC33 . In: Pflugers Arch . 447, No. 5, 2004, pp. 760-762. doi : 10.1007 / s00424-003-1071-6 . PMID 12739170 .
  35. Murer H, Forster I, Biber J: The sodium phosphate cotransporter family SLC34 . In: Pflugers Arch . 447, No. 5, 2004, pp. 763-767. doi : 10.1007 / s00424-003-1072-5 . PMID 12750889 .
  36. Ishida N, Kawakita M: Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35) . In: Pflugers Arch . 447, No. 5, 2004, pp. 768-775. doi : 10.1007 / s00424-003-1093-0 . PMID 12759756 .
  37. Boll M, Daniel H, Gasnier B: The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis family . In: Pflugers Arch . 447, No. 5, 2004, pp. 776-779. doi : 10.1007 / s00424-003-1073-4 . PMID 12748860 .
  38. Bartoloni L, Antonarakis SE: The human sugar-phosphate / phosphate exchanger family SLC37 . In: Pflugers Arch . 447, No. 5, 2004, pp. 780-783. doi : 10.1007 / s00424-003-1105-0 . PMID 12811562 .
  39. ^ Mackenzie B, Erickson JD: Sodium-coupled neutral amino acid (System N / A) transporters of the SLC38 gene family . In: Pflugers Arch . 447, No. 5, 2004, pp. 784-795. doi : 10.1007 / s00424-003-1117-9 . PMID 12845534 .
  40. Eide DJ: The SLC39 family of metal ion transporters . In: Pflugers Arch . 447, No. 5, 2004, pp. 796-800. doi : 10.1007 / s00424-003-1074-3 . PMID 12748861 .
  41. ^ McKie AT, Barlow DJ: The SLC40 basolateral iron transporter family (IREG1 / ferroportin / MTP1) . In: Pflugers Arch . 447, No. 5, 2004, pp. 801-806. doi : 10.1007 / s00424-003-1102-3 . PMID 12836025 .
  42. Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA: The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins: Introduction . In: Pflugers Arch . 447, No. 5, 2004, pp. 465-468. doi : 10.1007 / s00424-003-1192-y . PMID 14624363 .
  43. Nakhoul NL, Hamm LL: Non-erythroid Rh glycoproteins: a putative new family of mammalian ammonium transporters . In: Pflugers Arch . 447, No. 5, 2004, pp. 807-812. doi : 10.1007 / s00424-003-1142-8 . PMID 12920597 .
  44. Zhao R, Matherly LH, Goldman ID: Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. . In: Expert Rev Mol Med . 28, No. 11, 2009, p. E4. doi : 10.1017 / S1462399409000969 . PMID 19173758 .

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