Glucose-6-phosphate translocase

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Glucose-6-phosphate translocase
Properties of human protein
Mass / length primary structure 429 amino acids
Isoforms 4th
Identifier
Gene name SLC37A4
External IDs
Transporter classification
TCDB 2.A.1.4.5
designation Major Facilitator Superfamily / Organophosphate: P i Antiporter
Occurrence
Homology family G6PT
Parent taxon Euteleostomi

Glucose-6-phosphate translocase (G6PT) ( gene : SLC37A4 ) is the name of the protein in the membrane of the endoplasmic reticulum (ER) of vertebrates that transports glucose-6-phosphate from the cytosol into the ER. So it is a transport protein . Finally, the last sub-step of gluconeogenesis takes place in the ER . In the ER, G6PT forms a complex with glucose-6-phosphatase , which plays a central role in the energy metabolism through its production of glucose . In humans, G6PT is mainly produced in the liver and kidneys . Mutations in the SLC37A4 gene can lead to G6PT deficiency and this to von Gierke disease (type B).

The catalyzed membrane transport is:

Glucose-6-phosphate (zyt) + phosphate (endopl)     glucose-6-phosphate (endopl) + phosphate (zyt)

So it is an antiport .

As a central factor in energy metabolism, G6PT is the target for studies on the treatment of type 2 diabetes mellitus . In a study on mice, it was shown that careful blocking of G6PT improves diabetes symptoms while preventing glycogen storage diseases. Downregulation of G6PT expression may be the mechanism for krebsabtötende properties of curcumin .

Individual evidence

  1. ↑ UniProt O43826
  2. ↑ TCDB : 2.A.1
  3. ↑ Sloop KW, Showalter AD, Cox AL, et al : Specific reduction of hepatic glucose 6-phosphate transporter-1 ameliorates diabetes while avoiding complications of glycogen storage disease . In: J. Biol. Chem. . 282, No. 26, June 2007, pp. 19113-21. doi : 10.1074 / jbc.M610759200 . PMID 17478431 . . PMID 17478431 .
  4. ↑ Belkaid A, Copland IB, Massillon D, Annabi B: Silencing of the human microsomal glucose-6-phosphate translocase induces glioma cell death: potential new anticancer target for curcumin . In: FEBS Lett . . 580, No. 15, June 2006, pp. 3746-52. doi : 10.1016 / j.febslet.2006.05.071 . PMID 16777101 . . PMID 16777101 .

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