α-ketoglutarate malate carrier
| Α-ketoglutarate malate carrier | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 313 amino acids | |
| Secondary to quaternary structure | multipass membrane protein (6β) | |
| Identifier | ||
| Gene name | SLC25A11 | |
| External IDs | ||
| Transporter classification | ||
| TCDB | 2.A.29.2.2 | |
| designation | Mitochondrial Carrier (SLC25) | |
| Occurrence | ||
| Homology family | Mitochondrial carrier | |
| Parent taxon | Eukaryotes | |
The α-ketoglutarate malate carrier (OGC) (also mitochondrial 2-oxoglutarate malate carrier protein , gene: SLC25A11 ) is the protein that enables the exchange of α-ketoglutarate and malate through the inner cell membrane of mitochondria . It is one of two transport proteins in the malate-aspartate shuttle and is therefore essential for the energy metabolism in eukaryotes .
The catalyzed membrane transport is:
- α-ketoglutarate (outside) + malate (inside) ⇔ α-ketoglutarate (inside) + malate (outside)
So it is an antiport . Instead of malate, anions of other dicarboxylic acids and glutathione can also be transported.
See also
Individual evidence
- ↑ UniProt Q02978
- ↑ Q. Zhong et al .: Hepatic mitochondrial transport of glutathione: studies in isolated rat liver mitochondria and H4IIE rat hepatoma cells. Arch Biochem Biophys. 474/1/ 2008 : 119-27. PMID 18374655