α-ketoglutarate malate carrier
Α-ketoglutarate malate carrier | ||
---|---|---|
Properties of human protein | ||
Mass / length primary structure | 313 amino acids | |
Secondary to quaternary structure | multipass membrane protein (6β) | |
Identifier | ||
Gene name | SLC25A11 | |
External IDs | ||
Transporter classification | ||
TCDB | 2.A.29.2.2 | |
designation | Mitochondrial Carrier (SLC25) | |
Occurrence | ||
Homology family | Mitochondrial carrier | |
Parent taxon | Eukaryotes |
The α-ketoglutarate malate carrier (OGC) (also mitochondrial 2-oxoglutarate malate carrier protein , gene: SLC25A11 ) is the protein that enables the exchange of α-ketoglutarate and malate through the inner cell membrane of mitochondria . It is one of two transport proteins in the malate-aspartate shuttle and is therefore essential for the energy metabolism in eukaryotes .
The catalyzed membrane transport is:
- α-ketoglutarate (outside) + malate (inside) ⇔ α-ketoglutarate (inside) + malate (outside)
So it is an antiport . Instead of malate, anions of other dicarboxylic acids and glutathione can also be transported.
See also
Individual evidence
- ↑ UniProt Q02978
- ↑ Q. Zhong et al .: Hepatic mitochondrial transport of glutathione: studies in isolated rat liver mitochondria and H4IIE rat hepatoma cells. Arch Biochem Biophys. 474/1/ 2008 : 119-27. PMID 18374655