Mitochondrial dicarboxylate carrier
| Mitochondrial dicarboxylate carrier | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 287 amino acids | |
| Secondary to quaternary structure | multipass membrane protein (6β) | |
| Identifier | ||
| Gene name | SLC25A10 | |
| External IDs | ||
| Transporter classification | ||
| TCDB | 2.A.29.2.7 | |
| designation | Mitochondrial Carrier (SLC25) | |
| Occurrence | ||
| Homology family | Mitochondrial carrier | |
| Parent taxon | Eukaryotes | |
The mitochondrial dicarboxylate carrier (DIC) ( gene : SLC25A10 ) is the protein that enables the exchange of malate with anions through the inner cell membrane of mitochondria . It is responsible for the influx of malate into the mitochondria and is therefore essential for the energy metabolism in eukaryotes . In humans, DIC is particularly strongly expressed in the liver and kidneys .
The catalyzed membrane transport is:
- Dicarboxylate (outside) + anion (inside) Dicarboxylate (inside) + anion (outside)
So it is an antiport . Possible dicarboxylates are malate, malonate and succinate , while phosphate , sulphate , sulphite or thiosulphate can act as anions .
See also
Individual evidence
- ↑ D'Eustachio / Harris / reactome.org: malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]
- ↑ a b UniProt Q9UBX3
- ↑ Mizuarai S, Miki S, Araki H, Takahashi K, Kotani H: Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis . In: J. Biol. Chem. . 280, No. 37, September 2005, pp. 32434-41. doi : 10.1074 / jbc.M503152200 . PMID 16027120 .
- ↑ M. Crompton, F. Palmieri and a .: The transport of sulphate and sulphite in rat liver mitochondria. In: The Biochemical journal . Volume 142, Number 1, July 1974, pp. 127-137, ISSN 0264-6021 . PMID 4441366 . PMC 1168218 (free full text).