Tricarboxylate carrier
| Tricarboxylate carrier | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 298 amino acids | |
| Secondary to quaternary structure | multipass membrane protein (5 TMS) | |
| Identifier | ||
| Gene name | SLC25A1 | |
| External IDs | ||
| Transporter classification | ||
| TCDB | 2.A.29.7.2 | |
| designation | Mitochondrial Carrier (SLC25) | |
| Occurrence | ||
| Homology family | Mitochondrial carrier | |
| Parent taxon | Eukaryotes | |
Tricarboxylate carrier or citrate carrier (CIC, CTP) is the protein in the inner membrane of mitochondria that enables the exchange of citric acid for malate or phosphoenolpyruvate (PEP) through the mitochondrial membrane. So it is a transport protein . CTP is part of the so-called citrate shuttle and gluconeogenesis , and is therefore essential for the energy metabolism in eukaryotes . In humans, it is mainly localized in liver cells .
The catalyzed membrane transport is:
- Citrate / H + (inside) + malate (outside) Citrate / H + (outside) + malate (inside)
So it is an antiport . This partial transport of the citrate shuttle is electrically balanced by the transport of a proton by means of the pyruvate / H + symporter.
- Citrate / H + (outside) + PEP (inside) Citrate / H + (inside) + PEP (outside)
This second transport route is irreversible due to the potential of the inner membrane. A possible equalization transport is obviously unknown.
The expression of CIC is regulated by epigenetic mechanisms.
Individual evidence
- ↑ UniProt P53007
- ↑ a b D'Eustachio / Harris / reactome.org: phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]
- ↑ Iacobazzi V, V Infantino, Palmieri Q: Epigenetic mechanisms and Sp1 regulate mitochondrial citrate carrier gene expression . In: Biochem. Biophys. Res. Commun. . 376, No. 1, November 2008, pp. 15-20. doi : 10.1016 / j.bbrc.2008.08.015 . PMID 18706393 .