Thiamine transporter 1
| Thiamine transporter 1 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 497 amino acids | |
| Secondary to quaternary structure | multipass (12 TMS) membrane protein | |
| Identifier | ||
| Gene names | SLC19A2 ; TC1, ThTr1 | |
| External IDs | ||
| Transporter classification | ||
| TCDB | 2.A.48.2.1 | |
| designation | Reduced folate carrier (RFC) | |
| Occurrence | ||
| Homology family | Thiamine transporter | |
| Parent taxon | Eukaryotes | |
The thiamine transporter 1 (TC1, ThTr1) is the protein in the cell membrane of cells in all eukaryotes that enables thiamine (vitamin B1) to be transported into the cell. It is a transport protein that is highly specific, i.e. it only transports thiamine. In humans, TC1 can be found in all tissue types, but skeletal and cardiac muscle cells have a particularly large amount of TC1. TC1 is the SLC19A2 - gene encodes . Mutations in this gene can lead to a lack of TC1, which leads to a form of megaloblastic anemia ( Rogers syndrome ).
The catalyzed transport equilibrium is:
- Thiamine (outside) + nH + (inside) thiamine (inside) + nH + (outside)
Since the antiport is dependent on the proton gradient ΔP due to the chemiosmotic coupling , there is usually only one direction of equilibrium, namely the inward direction.
The TC1 homologue of the domestic cat ( Felis silvestris ) is the receptor for the feline leukosis virus FeLV-A.
Individual evidence
- ↑ UniProt O60779
- ↑ Mendoza R, Anderson MM, Overbaugh J: A putative thiamine transport protein is a receptor for feline leukemia virus subgroup A . In: J. Virol. . 80, No. 7, April 2006, pp. 3378-85. doi : 10.1128 / JVI.80.7.3378-3385.2006 . PMID 16537605 . PMC 1440375 (free full text).