Ferroportin
| Ferroportin-1 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 571 amino acids | |
| Secondary to quaternary structure | multipass membrane protein | |
| Identifier | ||
| Gene names | SLC40A1 ; FPN1 | |
| External IDs | ||
| Transporter classification | ||
| TCDB | 2.A.100 | |
| designation | Ferroportin family | |
| Occurrence | ||
| Homology family | Ferroportin-1 | |
| Parent taxon | Eukaryotes | |
Ferroportin-1 (FPN1, IREG1, SLC40A1) (. Lat ferrum = iron and portare wear =, bring) is a membrane transport - protein consisting of 571 amino acids which is produced in liver, spleen, kidneys, heart, intestine and placenta and occurs. It is found in the basolateral membrane (the membrane that points towards the blood) of epithelial cells, where it causes iron to be exported into the blood. Ferroportin can only bind and transport iron as Fe 2+ . After transport and oxidation to Fe 3+ by the plasma protein ceruloplasmin or the membrane protein hephestine , the binding to transferrin can take place for further transport in the blood.
When hepcidin binds to ferroportin, ferroportin is transported into the cell interior and broken down, so the cell can no longer release iron.
Mutations in the SLC40A1 gene can cause type 4 hemochromatosis in humans.
Individual evidence
- ^ P. Karlson, D. Doenecke, J. Koolman, G. Fuchs, W. Gerok: Karlsons Biochemie und Pathobiochemie. 15th edition, p. 600, Georg Thieme Verlag, 2005, ISBN 9783133578158 .
- ↑ McKie AT, Marciani P, Rolfs A, et al. : A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation . In: Mol. Cell . 5, No. 2, February 2000, pp. 299-309. PMID 10882071 .
- ↑ Wessling-Resnick M: Iron imports. III. Transfer of iron from the mucosa into circulation Archived from the original on October 10, 2008. Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. In: Am. J. Physiol. Gastrointest. Liver Physiol. . 290, No. 1, January 2006, pp. G1-6. doi : 10.1152 / ajpgi.00415.2005 . PMID 16354771 . PMC 2494859 (free full text). Retrieved March 21, 2010.
- ↑ UniProt entry
