Mitochondrial folate transporter
Mitochondrial folate transporter | ||
---|---|---|
Properties of human protein | ||
Mass / length primary structure | 315 amino acids | |
Secondary to quaternary structure | multipass (6 TMS) membrane protein | |
Identifier | ||
Gene name | SLC25A32 | |
External IDs | ||
Transporter classification | ||
TCDB | 2.A.29.10.2 | |
designation | Mitochondrial carrier | |
Occurrence | ||
Homology family | Mitochondrial carrier | |
Parent taxon | Eukaryotes |
The mitochondrial folate transporter (MFT) is a protein that facilitates the introduction and discharge of folic acid and its derivatives into cell mitochondria . So it is a transport protein . MFT occurs in animals; in humans it can be found in all types of tissue. A plant chloroplast folate transporter is so similar to MFT that it can act as a replacement in MFT-less hamster cell lines ; In contrast to animals, however, there are several chloroplast folate transporters in plants.
The catalyzed membrane transport is likely an antiport :
- S1 (outside) + S2 (inside) S1 (inside) + S2 (outside)
Several folic acid derivatives are accepted as a substrate. Nothing is known about the molecules transported in return.
Individual evidence
- ↑ UniProt Q9H2D1
- ↑ Bedhomme M, Hoffmann M, McCarthy EA, et al : Folate metabolism in plants: an Arabidopsis homolog of the mammalian mitochondrial folate transporter mediates folate import into chloroplasts . In: J. Biol. Chem. . 280, No. 41, October 2005, pp. 34823-31. doi : 10.1074 / jbc.M506045200 . PMID 16055441 .
- ↑ TCDB 2.A.29