GLUT-5

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GLUT-5

Existing structural data : 1yg1

Properties of human protein
Mass / length primary structure 501 amino acids
Secondary to quaternary structure multipass (12 TMS) membrane protein
Identifier
Gene names SLC2A5  ; GLUT5
External IDs
Transporter classification
TCDB 2.A.1.1.13
designation Major facilitator superfamily / glucose transporter
Occurrence
Parent taxon Chordates

The fructose transporter (GLUT5) ( gene : SLC2A5 ) is the protein in the cell membrane of intestinal epithelial cells of chordates that brings about the uptake of fructose into the cell by facilitated diffusion (passive transport). So it is a transport protein . In humans, GLUT5 is mainly produced in the small intestine and sperm , and to a lesser extent in the kidneys , muscles and fat cells. Nothing is known about mutations in the SLC2A5 gene.

GLUT5 in the apical membrane of small intestinal epithelial cells

function

The transport equation is:

So it is a uniport .

regulation

The rate of fructose uptake by GLUT5 is significantly influenced by diabetes mellitus , high blood pressure , obesity , fructose malabsorption and inflammation . Age-related changes in the fructose uptake ability cannot be explained by the expression rate of GLUT5. The fructose absorption is further improved in the simultaneous presence of glucose , while sorbitol has an inhibitory effect.

Individual evidence

  1. ↑ InterPro: IPR002442 Fructose transporter, type 5 (GLUT5)
  2. ↑ UniProt P22732
  3. ↑ OMIM: GLUT5
  4. ↑ TCDB : 2.A.1
  5. ↑ Douard V, Ferraris RP: Regulation of the fructose transporter GLUT5 in health and disease . In: Am. J. Physiol. Endocrinol. Metab. . 295, No. 2, August 2008, pp. E227-37. doi : 10.1152 / ajpendo.90245.2008 . PMID 18398011 .
  6. ↑ Litherland GJ, Hajduch E, Gould GW, Hundal HS: Fructose transport and metabolism in adipose tissue of Zucker rats: diminished GLUT5 activity during obesity and insulin resistance . In: Mol. Cell. Biochem. . 261, No. 1-2, June 2004, pp. 23-33. PMID 15362482 .
  7. ↑ Drozdowski LA, Woudstra TD, Wild GE, Clandinin MT, Thomson AB: Age-associated changes in intestinal fructose uptake are not explained by alterations in the abundance of GLUT5 or GLUT2 . In: J. Nutr. Biochem. . 15, No. 10, October 2004, pp. 630-7. doi : 10.1016 / j.jnutbio.2004.06.003 . PMID 15542355 .
  8. ^ Heinrich Kasper: Nutritional medicine and dietetics. 11th edition, Elsevier, Urban & Fischer-Verlag, 2009, ISBN 9783437420122 , p. 208

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