GLUT-3
| GLUT-3 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 496 amino acids | |
| Secondary to quaternary structure | multipass (12 TMS) membrane protein | |
| Identifier | ||
| Gene name | SLC2A3 | |
| External IDs | ||
| Transporter classification | ||
| TCDB | 2.A.1.1.12 | |
| designation | Major facilitator superfamily / glucose transporter | |
| Occurrence | ||
| Parent taxon | multicellular animals | |
GLUT-3 (glucose transporter type 3) ( gene : SLC2A3 ) is the name of the protein that is particularly localized in the cell membrane of the neurons of animals and facilitates the introduction and discharge of glucose and dehydroascorbate . It is a membrane transport protein . In humans, GLUT-3 is also present to a small extent in many other tissue types. In the house mouse ( Mus musculus ) it is one of the most common proteins in the sperm .
The oldest specimen in evolutionary terms was found in Nematostella vectensis , a sea anemone .
function
In neurons, the expression of GLUT-3 is regulated by the activity of AMP kinase . This process is an important part of the insensitivity of neurons to excitotoxicity (overactivation of glutamate receptors ). GLUT-3 is also indispensable in the early development phase of the embryo.
further reading
- Maulén NP, Henríquez EA, Kempe S, et al. : Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells . In: J. Biol. Chem. . 278, No. 11, March 2003, pp. 9035-41. doi : 10.1074 / jbc.M205119200 . PMID 12381735 .
- Rumsey SC, Kwon O, Xu GW, Burant CF, Simpson I, Levine M: Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid . In: J. Biol. Chem. . 272, No. 30, July 1997, pp. 18982-9. PMID 9228080 .
- Liang WJ, Johnson D, Jarvis SM: Vitamin C transport systems of mammalian cells . In: Mol. Membr. Biol . 18, No. 1, 2001, pp. 87-95. PMID 11396616 .
- Rivas CI, Zúñiga FA, Salas-Burgos A, Mardones L, Ormazabal V, Vera JC: Vitamin C transporters . In: J. Physiol. Biochem. . 64, No. 4, December 2008, pp. 357-75. PMID 19391462 .
Individual evidence
- ↑ InterPro: Glucose transporter, type 3 (GLUT3)
- ↑ UniProt P11168
- ↑ InterPro: IPR002945 Glucose transporter, type 3 (GLUT3)
- ^ Simpson IA, Dwyer D, Malide D, Moley KH, Travis A, Vannucci SJ: The facilitative glucose transporter GLUT3: 20 years of distinction . In: Am. J. Physiol. Endocrinol. Metab. . 295, No. 2, August 2008, pp. E242-53. doi : 10.1152 / ajpendo.90388.2008 . PMID 18577699 . PMC 2519757 (free full text).
- ↑ Weisová P, Concannon CG, Devocelle M, Prehn JH, Ward MW: Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons . In: J. Neurosci. . 29, No. 9, March 2009, pp. 2997-3008. doi : 10.1523 / JNEUROSCI.0354-09.2009 . PMID 19261894 .
- ↑ Schmidt S, Hommel A, Gawlik V, et al. : Essential role of glucose transporter GLUT3 for post-implantation embryonic development Archived from the original on July 5, 2010. Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. In: J. Endocrinol. . 200, No. 1, January 2009, pp. 23-33. doi : 10.1677 / JOE-08-0262 . PMID 18948350 . PMC 2632781 (free full text). Retrieved January 26, 2010.
Web links
- reactome: alpha-D-glucose (extracellular) ⇔ alpha-D-glucose (cytosol) [GLUT3]
- D'Eustachio / reactome: Dehydroascorbate transport across the plasma membrane