Carnitine-acylcarnitine transporter
| Carnitine-acylcarnitine transporter | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 301 amino acids | |
| Identifier | ||
| Gene names | SLC25A20 ; CAC, CACT | |
| External IDs | ||
| Transporter classification | ||
| TCDB | 2.A.29.8.3 | |
| designation | Mitochondrial carrier | |
| Occurrence | ||
| Parent taxon | Multicellular animals | |
The carnitine-acylcarnitine transporter (CACT) is the protein that catalyzes the opposite transport of L- carnitine from or acylcarnitine into the mitochondrion . This reaction is part of the fat metabolism and with it the burning ( β-oxidation ) of the transported fatty acids in the mitochondrial matrix can begin. It is a transporter from the class of mitochondrial carriers . Mutations in SLC25A20 - gene can (rare) CACT deficiency cause, which is fatal in severe cases shortly after birth.
The transport equation is:
- Acylcarnitine outside + carnitine inside = acylcarnitine inside + carnitine outside
So it is an antiport .
Individual evidence
- ↑ UniProt O43772
- ↑ Pierre G, Macdonald A, Gray G, Hendriksz C, Preece MA, Chakrapani A: Prospective treatment in carnitine-acylcarnitine translocase deficiency . In: J. Inherit. Metab. Dis. . 30, No. 5, October 2007, p. 815. doi : 10.1007 / s10545-007-0518-x . PMID 17508264 .
Web links
- Gopinathrao / reactome.org: Transport of palmitoyl carnitine into mitochondria
- Orphanet: Carnitine-acylcarnitine translocase deficiency.